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6-Amino-8-trifluoromethylphenanthridine

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Catalog No. T38186Cas No. 651055-83-3

6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine. It inhibits the protein folding activity of the ribosome (PFAR) at a concentration of 150 μM and directly competes with protein substrates for the ribosomal active site.

6-Amino-8-trifluoromethylphenanthridine

6-Amino-8-trifluoromethylphenanthridine

😃Good
Catalog No. T38186Cas No. 651055-83-3
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine. It inhibits the protein folding activity of the ribosome (PFAR) at a concentration of 150 μM and directly competes with protein substrates for the ribosomal active site.
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25 mg$1,11035 days
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Product Introduction

Bioactivity
Description
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine. It inhibits the protein folding activity of the ribosome (PFAR) at a concentration of 150 μM and directly competes with protein substrates for the ribosomal active site.
Chemical Properties
Molecular Weight262.23
FormulaC14H9F3N2
Cas No.651055-83-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: Soluble
DMSO: Soluble

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

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