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PROTAC BRD4 Degrader-5

Name: PROTAC BRD4 Degrader-5
Brand: TargetMol
SKU: T36242
Rating: 4.5 (1 reviews)

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Catalog No. T36242Cas No. 2409538-70-9

PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.

PROTAC BRD4 Degrader-5

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Catalog No. T36242Cas No. 2409538-70-9

PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$283	Inquiry	Inquiry
5 mg	$619	Inquiry	Inquiry
10 mg	$993	Inquiry	Inquiry
25 mg	$1,470	Inquiry	Inquiry
50 mg	$1,990	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$1,080	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.
In vitro	5-100 nM PROTAC BRD4 Degrader-5 treatment of MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells for 4 h was able to degrade BRD4 in the cells. [1]

Chemical Properties

Molecular Weight	1016.67
Formula	C₅₀H₆₂ClN₉O₈S₂
Cas No.	2409538-70-9
Smiles	CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (142.62 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (4.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9836 mL	4.9180 mL	9.8360 mL	49.1802 mL
5 mM	0.1967 mL	0.9836 mL	1.9672 mL	9.8360 mL
10 mM	0.0984 mL	0.4918 mL	0.9836 mL	4.9180 mL
20 mM	0.0492 mL	0.2459 mL	0.4918 mL	2.4590 mL
50 mM	0.0197 mL	0.0984 mL	0.1967 mL	0.9836 mL
100 mM	0.0098 mL	0.0492 mL	0.0984 mL	0.4918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc