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RAB7A Protein, Rat, Recombinant (His)

Catalog No. TMPY-04152
Synonyms: RAB7A, member RAS oncogene family, Rab7

RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is important for peripherin organization and function. Besides, disease-causing RAB7A mutant proteins bind more strongly to peripherin and their expression causes a significant increase in the amount of soluble peripherin. The altered interaction between disease-causing RAB7A mutants and peripherin could play an important role in CMT2B neuropathy.

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RAB7A Protein, Rat, Recombinant (His)
Pack Size Availability Price/USD Quantity
100 μg 5 days $ 498.00
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Biological Description
Technical Params
Product Properties
Description RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is important for peripherin organization and function. Besides, disease-causing RAB7A mutant proteins bind more strongly to peripherin and their expression causes a significant increase in the amount of soluble peripherin. The altered interaction between disease-causing RAB7A mutants and peripherin could play an important role in CMT2B neuropathy.
Species Rat
Expression System E. coli
Tag His
Accession Number A6IB33
Synonyms RAB7A, member RAS oncogene family, Rab7
Construction A DNA sequence encoding the rat Rab7a (NP_076440.1) (Met1-Cys207) was expressed with a polyhistidine tag at the N-terminus.
Protein Purity > 90 % as determined by SDS-PAGE.
Molecular Weight 25.7 kDa (predicted)
Endotoxin Please contact us for more information.
Formulation Lyophilized from sterile PBS, 10 % glycerol. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is important for peripherin organization and function. Besides, disease-causing RAB7A mutant proteins bind more strongly to peripherin and their expression causes a significant increase in the amount of soluble peripherin. The altered interaction between disease-causing RAB7A mutants and peripherin could play an important role in CMT2B neuropathy.

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Keywords

RAB7A Protein, Rat, Recombinant (His) RAB7A, member RAS oncogene family Rab7 recombinant recombinant-proteins proteins protein

 

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