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Hemojuvelin Protein, Cynomolgus, Recombinant (His)
(Synonyms: RGM-C, Rgmc, HFE2, hemochromatosis type 2 (juvenile)) Copy Product InfoSynonyms: RGM-C, Rgmc, HFE2, hemochromatosis type 2 (juvenile)
Catalog No. TMPY-04045 Copy Product Info
Hemojuvelin Protein, Cynomolgus, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 40.2 kDa and the accession number is A0A2K5TJX5.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $68 | 7-10 days | 7-10 days | |
| 10 µg | $108 | 7-10 days | 7-10 days | |
| 20 µg | $178 | 7-10 days | 7-10 days | |
| 50 µg | $359 | 7-10 days | 7-10 days | |
| 100 µg | $696 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Cynomolgus RGM-C, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-RGM-C Antibody, hFc Tag with the EC50 of 1.7 ng/ml determined by ELISA. |
| Description | Hemojuvelin Protein, Cynomolgus, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 40.2 kDa and the accession number is A0A2K5TJX5. |
| Species | Cynomolgus |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | XP_005542141.1 |
| Construction | Gln36-Asp401 |
| Protein Purity | > 95 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | RGM-C, Rgmc, HFE2, hemochromatosis type 2 (juvenile) |
| Research Background | Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein that belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homolog of the Netrin receptor deleted in colon cancer. In mammals, the RGM family consists of three glycoproteins that have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway that activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH). |
| Molecular Weight | The protein has a predicted MW of 40 kDa (mature)&26 kDa (C-terminus peptide)&14 kDa (N-terminus peptide). Due to enzyme lysis and glycosylation, the protein migrates to 50-60 kDa&30-40 kDa&20-25 kDa based on Bis-Tris PAGE result. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Hemojuvelin Protein, Cynomolgus, Recombinant (His) chemical structure | Hemojuvelin Protein, Cynomolgus, Recombinant (His) molecular weight
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