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Alloepipregnanolone
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Catalog No. T7646Cas No. 516-55-2
Alloepipregnanolone is a pregnane with anesthetic, hypnotic, and sedative properties.
Alloepipregnanolone
Copy Product Info🥰Excellent
Purity: 99.49%
Catalog No. T7646Cas No. 516-55-2
Alloepipregnanolone is a pregnane with anesthetic, hypnotic, and sedative properties.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $30 | In Stock | In Stock | |
| 50 mg | $37 | In Stock | In Stock | |
| 100 mg | $50 | In Stock | In Stock | |
| 500 mg | $113 | In Stock | In Stock | |
| 1 g | $163 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.49%
Appearance:Solid
Color:White
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Product Introduction
Alloepipregnanolone AI Summary
Alloepipregnanolone exhibits a range of bioactivities, including significant inhibitory effects on various enzymes and interactions. It inhibits Polymerase Iota with a potency of 89125.1 nM and demonstrates effectiveness against TGF-b with a potency of 562.3 nM in the cytotox counterscreen assay. Additionally, it inhibits Vif-A3F interactions at a potency of 3162.3 nM and human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 29092.9 nM. It also shows inhibitory activity against USP1/UAF1 with a potency of 3162.3 nM in a primary screen assay. Furthermore, Alloepipregnanolone inhibits human recombinant G6PD, expressed in Escherichia coli JM109 (DE3) cells, with an IC50 value of 4300.0 nM, measured by the production of NADPH using the Amplite fluorimetric assay. In terms of central nervous system activity, it demonstrates anticonvulsant effects in a 6-Hz induced seizure mouse model, offering protection at ED50 values greater than 100.0 mg/kg. The compound also enhances NAS-mediated GABA tonic effects with a fold potentiation of 0.76..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Alloepipregnanolone is a pregnane with anesthetic, hypnotic, and sedative properties. |
| Molecular Weight | 318.49 |
| Formula | C21H34O2 |
| Cas No. | 516-55-2 |
| Smiles | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |
| Relative Density. | 1.053g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9.52 mg/mL (29.89 mM), Sonication is recommended.  Ethanol: 10 mg/mL (31.4 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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