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Licoricesaponin A3

Name: Licoricesaponin A3
Brand: TargetMol
SKU: TN1865
Rating: 4.5 (1 reviews)

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Catalog No. TN1865Cas No. 118325-22-7

Licoricesaponin A3 is a terpenoid saponin extracted from Gymnostachyum febrifugum Benth., which has good affinity for 5-LOX receptors.

Licoricesaponin A3

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Catalog No. TN1865Cas No. 118325-22-7

Licoricesaponin A3 is a terpenoid saponin extracted from Gymnostachyum febrifugum Benth., which has good affinity for 5-LOX receptors.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$2,198	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description

Licoricesaponin A3 is a terpenoid saponin extracted from Gymnostachyum febrifugum Benth., which has good affinity for 5-LOX receptors.

In vitro

Fourteen triterpenoid saponins were isolated from the 50% ethanol extract of the root and rhizome of Glycyrrhiza uralensis, namely glycyrrhizin C (1), glycyrrhizin D (2), glycyrrhizin A3 (3), glycyrrhizin F (4), 22β-acetoxyglycyrrhizin (5), 24-hydroxyglycyrrhizin E2 (6), glycyrrhizin E2 (7), glycyrrhizin G2 (8), 22β-acetoxyglycyrrhizin (9), 3β-O-[β-D-glucuronopyranosyl-(12)-β-D-glucuronopyranosyl]-glycyrrhizinol (10), arabinoside (11), glycyrrhizin J2 (12), glycyrrhizin (13) and glycyrrhetinic acid monoglucuronide (14). Compounds 1 to 14 have cytotoxic activity against human cancer cell lines MGC-803, SW620, and SMMC-7721, with IC50 values greater than 100 μM; the aglycones of compounds 2, 6 to 8, and 13 have inhibitory effects on cancer cell growth, with IC50 values ranging from 18.3 to 41.6 μM. [1]

Chemical Properties

Molecular Weight	985.07
Formula	C₄₈H₇₂O₂₁
Cas No.	118325-22-7
Smiles	C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O[C@H]4[C@H](O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O4)CC3)[H])(C(=O)C=C6[C@@]2(C)CC[C@]7(C)[C@]6(C[C@](C(O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)=O)(C)CC7)[H])[H]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc