Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 463.00 | |
25 mg | In stock | $ 763.00 | |
50 mg | In stock | $ 1,070.00 | |
100 mg | In stock | $ 1,430.00 | |
500 mg | In stock | $ 2,890.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer. |
In vitro | In MCF-7 cells, ErSO (1-1000 nM) inhibits cell viability with an IC50 of 20.3 nM. ErSO (1 μM) rapidly kills ERα-positive breast cancer cells in TYS and TDG cells and induces rapid killing of ERα-positive MCF-7 human breast cancer cells[1]. |
In vivo | ErSO (10 and 40 mg/kg; p.o.) induces >100000-fold regression (to undetectable amounts) within 14 days and >10000-fold regression of TYS-luciferase-expressing breast tumors in all five mice. In Nu/J mice, ErSO (10 or 40 mg/kg; p.o.) eliminates tumors with >90% reduction in all cases[1]. |
Molecular Weight | 453.33 |
Formula | C22H13F6NO3 |
CAS No. | 2407860-35-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (220.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ErSO 2407860-35-7 Others inhibitor inhibit