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ErSO

Name: ErSO
Brand: TargetMol
SKU: T39980
Price: 858 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T39980Cas No. 2407860-35-7

ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.

ErSO

🥰Excellent

Purity: 98.36%

Catalog No. T39980Cas No. 2407860-35-7

ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$173	In Stock
10 mg	$277	In Stock
25 mg	$457	In Stock
50 mg	$642	In Stock
100 mg	$858	In Stock
500 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$190	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.36%

ee:100%

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COA HNMR LCMS CSFC

Product Introduction

Bioactivity

Description	ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.
In vitro	In MCF-7 cells, ErSO (1-1000 nM) inhibits cell viability with an IC50 of 20.3 nM. ErSO (1 μM) rapidly kills ERα-positive breast cancer cells in TYS and TDG cells and induces rapid killing of ERα-positive MCF-7 human breast cancer cells[1].
In vivo	ErSO (10 and 40 mg/kg; p.o.) induces >100000-fold regression (to undetectable amounts) within 14 days and >10000-fold regression of TYS-luciferase-expressing breast tumors in all five mice. In Nu/J mice, ErSO (10 or 40 mg/kg; p.o.) eliminates tumors with >90% reduction in all cases[1].

Chemical Properties

Molecular Weight	453.33
Formula	C₂₂H₁₃F₆NO₃
Cas No.	2407860-35-7
Smiles	Oc1ccc(cc1)[C@@]1(C(=O)Nc2c1cccc2C(F)(F)F)c1ccc(OC(F)(F)F)cc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (220.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2059 mL	11.0295 mL	22.0590 mL	110.2949 mL
5 mM	0.4412 mL	2.2059 mL	4.4118 mL	22.0590 mL
10 mM	0.2206 mL	1.1029 mL	2.2059 mL	11.0295 mL
20 mM	0.1103 mL	0.5515 mL	1.1029 mL	5.5147 mL
50 mM	0.0441 mL	0.2206 mL	0.4412 mL	2.2059 mL
100 mM	0.0221 mL	0.1103 mL	0.2206 mL	1.1029 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc