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D-Ala-D-Ala trifluoroacetate

Name: D-Ala-D-Ala trifluoroacetate
Brand: TargetMol
SKU: T77204L
Rating: 4.5 (1 reviews)

Catalog No. T77204L Copy Product Info

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D-Ala-D-Ala trifluoroacetate (free base, CAS 923-16-0) is an endogenous bacterial metabolite. As the terminal structure of the peptide segment in bacterial peptidoglycan monomers, it can serve as a substrate to participate in transpeptidation reactions. D-Ala-D-Ala trifluoroacetate (free base, CAS 923-16-0) is catalyzed and synthesized by D-alanine-D-alanine ligase.

D-Ala-D-Ala trifluoroacetate

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Catalog No. T77204L

Cas No. 87155-77-9

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

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Product Introduction

Bioactivity

Description	D-Ala-D-Ala trifluoroacetate (free base, CAS 923-16-0) is an endogenous bacterial metabolite. As the terminal structure of the peptide segment in bacterial peptidoglycan monomers, it can serve as a substrate to participate in transpeptidation reactions. D-Ala-D-Ala trifluoroacetate (free base, CAS 923-16-0) is catalyzed and synthesized by D-alanine-D-alanine ligase.
In vitro	Methods: The dadA::Tn mutant was treated with 15 mM D-Ala-D-Ala trifluoroacetate, and changes in its GRABS score were detected. Results: 15 mM D-Ala-D-Ala trifluoroacetate decreased the GRABS score of the dadA::Tn mutant by 30% [3].

Chemical Properties

Molecular Weight	274.20
Formula	C₈H₁₃F₃N₂O₅
Cas No.	87155-77-9
Smiles	OC(C(F)(F)F)=O.C[C@@H](N)C(N[C@H](C)C(O)=O)=O
Relative Density.	no data available
Sequence	H-D-Ala-D-Ala-OH.TFA
Sequence Short	AA

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1.6 mg/mL (5.84 mM), when pH is adjusted to 5 with HCl.

H2O: 80 mg/mL (291.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.6470 mL	18.2349 mL	36.4697 mL	182.3487 mL
5 mM	0.7294 mL	3.6470 mL	7.2939 mL	36.4697 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.3647 mL	1.8235 mL	3.6470 mL	18.2349 mL
20 mM	0.1823 mL	0.9117 mL	1.8235 mL	9.1174 mL
50 mM	0.0729 mL	0.3647 mL	0.7294 mL	3.6470 mL
100 mM	0.0365 mL	0.1823 mL	0.3647 mL	1.8235 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DAlaDAlatrifluoroacetate（923160freebase）