Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DS20362725 is an agonist of estrogen-related receptor α (ERRα) that is able to be used for the metabolic disorders research, for example, type 2 diabetes mellitus (T2DM). The IC 50 value of DS20362725 inhibiting the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) is 0.6 μM [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,200.00 | |
50 mg | 6-8 weeks | $ 1,570.00 | |
100 mg | 6-8 weeks | $ 2,570.00 |
Description | DS20362725 is an agonist of estrogen-related receptor α (ERRα) that is able to be used for the metabolic disorders research, for example, type 2 diabetes mellitus (T2DM). The IC 50 value of DS20362725 inhibiting the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) is 0.6 μM [1]. |
In vitro | DS20362725 (compound 3d; concentrations: 0.002, 0.006, 0.017, 0.051, 0.015, 0.046, 1.4, 4.2, 12.5 μg/mL; duration: 18 h) effectively suppresses the transcriptional activity of the full-length ERRα in MG63 cells, achieving an EC50 of 1.1 μM [1]. |
Molecular Weight | 310.39 |
Formula | C19H22N2O2 |
CAS No. | 2735803-20-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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DS20362725 2735803-20-8 inhibitor inhibit