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PAPA NONOate

Catalog No. T74048 CAS 146672-58-4

PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.

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PAPA NONOate, CAS 146672-58-4

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.
In vitro	Incubation with PAPA NONOate (50 μM) for 12 hours significantly reduced the increase in caspase-3-like activity induced by caspase-3 overexpression by 70%[1].
In vivo	In phosphate-buffered saline, treatment of rat dorsal skin wounds with 100 μM PAPA NONOate resulted in improved wound healing rates in the treated group[2].

Molecular Weight	176.22
Formula	C6H16N4O2
CAS No.	146672-58-4

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 30 mg/mL (170.25 mM), Sonication is recommended.

References and Literature

1. Rössig L,et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274(11):6823-6. 2. N Dashti, et al. Study of the effect of PAPA NONOate on the rate of diabetic wound healing. African Journal of Biotechnology. 2014.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library

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Related compounds with same targets

Methyl anisate D-(-)-Quinic acid D(+)-Raffinose pentahydrate Dimethyl fumarate Elaidic acid Coenzyme Q9 Potassium gluconate L-Kynurenine

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Keywords

PAPA NONOate 146672-58-4 Immunology/Inflammation Metabolism Endogenous Metabolite NO Synthase inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.