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PAPA NONOate

🥰Excellent
Catalog No. T74048Cas No. 146672-58-4

PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.

PAPA NONOate

PAPA NONOate

🥰Excellent
Purity: 98%
Catalog No. T74048Cas No. 146672-58-4
PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$49-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98%
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Product Introduction

Bioactivity
Description
PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.
In vitro
Incubation with PAPA NONOate (50 μM) for 12 hours significantly reduced the increase in caspase-3-like activity induced by caspase-3 overexpression by 70%[1].
In vivo
In phosphate-buffered saline, treatment of rat dorsal skin wounds with 100 μM PAPA NONOate resulted in improved wound healing rates in the treated group[2].
Chemical Properties
Molecular Weight176.22
FormulaC6H16N4O2
Cas No.146672-58-4
SmilesO=NN(O)N(CCC)CCCN
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 30 mg/mL (170.25 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM5.6747 mL28.3736 mL56.7472 mL283.7362 mL
5 mM1.1349 mL5.6747 mL11.3494 mL56.7472 mL
10 mM0.5675 mL2.8374 mL5.6747 mL28.3736 mL
20 mM0.2837 mL1.4187 mL2.8374 mL14.1868 mL
50 mM0.1135 mL0.5675 mL1.1349 mL5.6747 mL
100 mM0.0567 mL0.2837 mL0.5675 mL2.8374 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

NOSynthaseNO SynthaseEndogenousMetaboliteEndogenous Metabolite
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