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PAPA NONOate

Name: PAPA NONOate
Brand: TargetMol
SKU: T74048
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74048Cas No. 146672-58-4

PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.

PAPA NONOate

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Purity: 98%

Catalog No. T74048Cas No. 146672-58-4

PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$49	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.
In vitro	Incubation with PAPA NONOate (50 μM) for 12 hours significantly reduced the increase in caspase-3-like activity induced by caspase-3 overexpression by 70%[1].
In vivo	In phosphate-buffered saline, treatment of rat dorsal skin wounds with 100 μM PAPA NONOate resulted in improved wound healing rates in the treated group[2].

Chemical Properties

Molecular Weight	176.22
Formula	C₆H₁₆N₄O₂
Cas No.	146672-58-4
Smiles	O=NN(O)N(CCC)CCCN

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30 mg/mL (170.24 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.6747 mL	28.3736 mL	56.7472 mL	283.7362 mL
5 mM	1.1349 mL	5.6747 mL	11.3494 mL	56.7472 mL
10 mM	0.5675 mL	2.8374 mL	5.6747 mL	28.3736 mL
20 mM	0.2837 mL	1.4187 mL	2.8374 mL	14.1868 mL
50 mM	0.1135 mL	0.5675 mL	1.1349 mL	5.6747 mL
100 mM	0.0567 mL	0.2837 mL	0.5675 mL	2.8374 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc