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Eniporide

Name: Eniporide
Brand: TargetMol
SKU: T2089
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2089Cas No. 176644-21-6

Eniporide is a Na(+)/H(+) exchange inhibitor.

Eniporide

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Purity: 99.26%

Catalog No. T2089Cas No. 176644-21-6

Eniporide is a Na(+)/H(+) exchange inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$70	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$207	In Stock	In Stock
50 mg	$311	In Stock	In Stock
100 mg	$449	In Stock	In Stock
200 mg	$633	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.26%

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Eniporide AI Summary

Eniporide exhibits potent inhibition of the sodium/hydrogen exchanger isoform NHE-1 with an IC50 value ranging from 5.0 nM to 400.0 nM, depending on the assay conditions. It demonstrates a substantial selectivity over other isoforms such as NHE-2, NHE-3, and NHE-5, showing significantly higher IC50 values for these isoforms: 9200.0 nM to 17000.0 nM for NHE-2, up to 100000.0 nM for NHE-3, and greater than 30000.0 nM for NHE-5. The compound also inhibits sodium uptake in acidified rabbit erythrocytes with an IC50 of 8.0 nM and reduces acid-induced swelling in human platelets with an IC50 of 32.0 nM. It has been tested for pharmacokinetic properties in humans, showing a volume of distribution at steady state (Vdss) of 1.1 L/kg, a half-life (T1/2) of 2.2 hours, a mean residence time (MRT) of 2.3 hours, and a clearance rate (CL) of 8.2 mL/min/kg. In Sprague-Dawley rats, it has an oral bioavailability of 65.0%, a Vdss of 0.5 L/kg, an MRT of 0.4 hours, and a clearance of 28.0% relative to hepatic blood flow. Additionally, Eniporide has shown some antiviral activity against SARS-CoV-2, inhibiting the 3CL-Pro protease by 14.44% at a concentration of 20 µM and reducing cytotoxicity in VERO-6 cells with a minimal inhibitory effect..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Eniporide is a Na(+)/H(+) exchange inhibitor.

Chemical Properties

Molecular Weight	320.37
Formula	C₁₄H₁₆N₄O₃S
Cas No.	176644-21-6
Smiles	Cc1cc(c(cc1C(=O)NC(N)=N)S(C)(=O)=O)-n1cccc1
Relative Density.	1.41g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (78.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1214 mL	15.6070 mL	31.2139 mL	156.0695 mL
5 mM	0.6243 mL	3.1214 mL	6.2428 mL	31.2139 mL
10 mM	0.3121 mL	1.5607 mL	3.1214 mL	15.6070 mL
20 mM	0.1561 mL	0.7803 mL	1.5607 mL	7.8035 mL
50 mM	0.0624 mL	0.3121 mL	0.6243 mL	3.1214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc