keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent transcription5. Interestingly, the COOH terminus of 53BP1 contains tandem BRCA1 COOH terminus (BRCT) motifs.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 50.00 | |
5 mg | Inquiry | $ 143.00 | |
10 mg | Inquiry | $ 235.00 | |
25 mg | Inquiry | $ 329.00 |
Description | Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent transcription5. Interestingly, the COOH terminus of 53BP1 contains tandem BRCA1 COOH terminus (BRCT) motifs. |
In vitro | 53BP1 becomes hyperphosphorylated and rapidly relocates to the sites of DNA strand breaks in response to ionizing radiation. 53BP1 foci formation is reduced in ATM-deficient cells and can be inhibited by wortmannin in ATM wild-type cells. Moreover, radiation-induced hyperphosphorylation of 53BP1 is absent in cells treated with wortmannin, as well as in ATM-deficient cells. 53BP1 participates in DNA damage–signaling pathways and is regulated by ATM after γ-radiation6. |
Molecular Weight | 1242.38 |
Formula | C57H87N13O18 |
CAS No. | TP2299 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≥124.2mg/mL
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tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] TP2299 Others tumor protein p-53 binding protein fragment [Homo sapiens]/[Mus musculus] inhibitor inhibit