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3'-Deoxy-3'-fluoroadenosine

Name: 3'-Deoxy-3'-fluoroadenosine
Brand: TargetMol
SKU: TNU0007
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TNU0007Cas No. 75059-22-2

3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue with broad anti-tumor and anti-viral activity, showing inhibitory effects on tick-borne encephalitis virus (TBEV), Zika virus, and West Nile virus (WNV) with EC50 values of 1.1 μM, 0.1 μM and [4.7 ± 1.5] μM, respectively. It is useful for studying tumor diseases.

3'-Deoxy-3'-fluoroadenosine

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Purity: 99.84%

Catalog No. TNU0007Cas No. 75059-22-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$106	In Stock	In Stock
50 mg	$172	In Stock	In Stock
100 mg	$277	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

3'-Deoxy-3'-fluoroadenosine AI Summary

3'-Deoxy-3'-fluoroadenosine exhibits a variety of bioactivities, notably altering cell morphology in PRK, HeLa, and Vero B cells at 40.0 µg/mL. It reduces virus-induced cytopathogenicity against HSV-1, HSV-2, Vaccinia virus, Vesicular stomatitis virus types 1 and 2, and Polio virus type-1, with effective concentrations ranging from 10.0 to 40.0 µg/mL and MIC values between 1.0 and 7.0 µg/mL. The compound demonstrates cytotoxic effects on various cell lines, including Murine leukemia L1210, Human B-lymphoblast Raji, and Human T-lymphoblast Molt/4F and MT-4, with IC50 values from 0.22 to 28.0 µg/mL. It inhibits HCV NS5B-mediated RNA synthesis (IC50 = 28000.0 nM) and HCV RNA replication (EC50 = 1200.0 nM). Furthermore, it shows 100% growth inhibition of Trichomonas vaginalis T1 at 100 µM after 24 hours and an IC50 value of 1610.0 nM. The compound has potent antitrypanosomal activity against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense, with EC50 values of 32.0 nM and 17.0 nM, respectively, and against Trypanosoma cruzi Tulahuen CL2 in human MRC5 cells (EC50 = 550.0 nM). Its antileishmanial activity against Leishmania infantum MHOM/MA(BE)/67 in mouse peritoneal macrophages is marked by an EC50 of 27500.0 nM, with favorable selectivity indices indicating higher potency against parasites compared to mammalian cell cytotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	269.23
Formula	C₁₀H₁₂FN₅O₃
Cas No.	75059-22-2
Smiles	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](F)[C@H]1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (185.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (9.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7143 mL	18.5715 mL	37.1430 mL	185.7148 mL
5 mM	0.7429 mL	3.7143 mL	7.4286 mL	37.1430 mL
10 mM	0.3714 mL	1.8571 mL	3.7143 mL	18.5715 mL
20 mM	0.1857 mL	0.9286 mL	1.8571 mL	9.2857 mL
50 mM	0.0743 mL	0.3714 mL	0.7429 mL	3.7143 mL
100 mM	0.0371 mL	0.1857 mL	0.3714 mL	1.8571 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc