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C18 Phytoceramide (t18:0/18:0) (Synonyms: N-Stearoyl phytosphingosine, Ceramide 3)

Catalog No. T37458 Copy Product Info
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C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid present in Saccharomyces cerevisiae, wheat grains, and the mammalian epidermal stratum corneum, composed of a phytosphingosine backbone amide-linked to a C18 fatty acid chain, C18 Phytoceramide regulates apoptosis, cell differentiation, smooth muscle cell proliferation, and mitochondrial respiratory chain activity while inhibiting IL-4, TNF-α, c-Jun, and NF-κB expression in histone-stimulated murine skin tissue, supporting its use in dermatological, inflammatory, and cosmetic skin barrier research.

C18 Phytoceramide (t18:0/18:0)

Copy Product Info
🥰Excellent
Catalog No. T37458
Synonyms N-Stearoyl phytosphingosine, Ceramide 3

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid present in Saccharomyces cerevisiae, wheat grains, and the mammalian epidermal stratum corneum, composed of a phytosphingosine backbone amide-linked to a C18 fatty acid chain, C18 Phytoceramide regulates apoptosis, cell differentiation, smooth muscle cell proliferation, and mitochondrial respiratory chain activity while inhibiting IL-4, TNF-α, c-Jun, and NF-κB expression in histone-stimulated murine skin tissue, supporting its use in dermatological, inflammatory, and cosmetic skin barrier research.

C18 Phytoceramide (t18:0/18:0)
Cas No. 34354-88-6
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$12735 days35 days
5 mg$31935 days35 days
10 mg$47835 days35 days
25 mg$76835 days35 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid present in Saccharomyces cerevisiae, wheat grains, and the mammalian epidermal stratum corneum, composed of a phytosphingosine backbone amide-linked to a C18 fatty acid chain, C18 Phytoceramide regulates apoptosis, cell differentiation, smooth muscle cell proliferation, and mitochondrial respiratory chain activity while inhibiting IL-4, TNF-α, c-Jun, and NF-κB expression in histone-stimulated murine skin tissue, supporting its use in dermatological, inflammatory, and cosmetic skin barrier research.
SynonymsN-Stearoyl phytosphingosine, Ceramide 3
Chemical Properties
Molecular Weight583.98
FormulaC36H73NO4
Cas No.34354-88-6
Smiles[C@H]([C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)(NC(CCCCCCCCCCCCCCCCC)=O)CO
Relative Density.0.994-1.014 g/cm3 at 20℃
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Chloroform:Methanol (1:1): Soluble, Heating is recommended.
Methanol: 0.8 mg/mL (1.37 mM), Sonication is recommended.
Solution Preparation Table
Methanol
1mg5mg10mg50mg
1 mM1.7124 mL8.5619 mL17.1239 mL85.6194 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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