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Soyasapogenol A

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Catalog No. TN2224Cas No. 508-01-0

Soyasapogenol A is a natural triterpene that protects against the concanavalin A-induced hepatitis immune response, inhibits hepatocyte apoptosis, and suppresses elevated plasma TNF-α levels. Soyasapogenol A also induces apoptosis in Hep-G2 cells.

Soyasapogenol A
Other Forms of Soyasapogenol A:
Soyasapogenol A (Standard)TMSM-1152508-01-0
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Soyasapogenol A

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Purity: 99.13%
Catalog No. TN2224Cas No. 508-01-0
Soyasapogenol A is a natural triterpene that protects against the concanavalin A-induced hepatitis immune response, inhibits hepatocyte apoptosis, and suppresses elevated plasma TNF-α levels. Soyasapogenol A also induces apoptosis in Hep-G2 cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$133-In Stock
5 mg$283-In Stock
10 mg$419-In Stock
25 mg$686-In Stock
50 mg$953-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.13%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Soyasapogenol A is a natural triterpene that protects against the concanavalin A-induced hepatitis immune response, inhibits hepatocyte apoptosis, and suppresses elevated plasma TNF-α levels. Soyasapogenol A also induces apoptosis in Hep-G2 cells.
In vitro
Soyasapogenol A (1-64 μM, 48 hours) showed significant cytotoxicity against multiple cancer cell lines (U2OS, SKOV3, Saos-2, MDA-MB-231) and also exhibited notable cytotoxicity in p53-deficient cancer cells (SKOV3 and Saos-2) [4].
In vivo
Soyasapogenol A (15 mg/kg, intragastric administration) significantly inhibited the growth of tumor volume in the subcutaneous parazacco spilurus subsp. spilurus xenograft model of SKOV-3 cells and effectively reduced lung metastasis of tumors in the tail vein parazacco spilurus subsp. spilurus xenograft model of SKOV-3 cells [4].
Chemical Properties
Molecular Weight474.72
FormulaC30H50O4
Cas No.508-01-0
Smiles[H][C@@]12CC(C)(C)[C@@H](O)[C@@H](O)[C@]1(C)CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)[C@](C)(CO)[C@]3([H])CC[C@@]12C
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (168.52 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1065 mL10.5325 mL21.0650 mL105.3252 mL
5 mM0.4213 mL2.1065 mL4.2130 mL21.0650 mL
10 mM0.2107 mL1.0533 mL2.1065 mL10.5325 mL
20 mM0.1053 mL0.5266 mL1.0533 mL5.2663 mL
50 mM0.0421 mL0.2107 mL0.4213 mL2.1065 mL
100 mM0.0211 mL0.1053 mL0.2107 mL1.0533 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

TNF-αSoyasapogenol A
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