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Soyasapogenol A

Name: Soyasapogenol A
Brand: TargetMol
SKU: TN2224
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2224Cas No. 508-01-0

Soyasapogenol A is a natural triterpene that protects against the concanavalin A-induced hepatitis immune response, inhibits hepatocyte apoptosis, and suppresses elevated plasma TNF-α levels. Soyasapogenol A also induces apoptosis in Hep-G2 cells.

Soyasapogenol A

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Purity: 99.13%

Catalog No. TN2224Cas No. 508-01-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$133	-	In Stock
5 mg	$283	-	In Stock
10 mg	$419	-	In Stock
25 mg	$686	-	In Stock
50 mg	$953	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.13%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Soyasapogenol A is a natural triterpene that protects against the concanavalin A-induced hepatitis immune response, inhibits hepatocyte apoptosis, and suppresses elevated plasma TNF-α levels. Soyasapogenol A also induces apoptosis in Hep-G2 cells.
In vitro	Soyasapogenol A (1-64 μM, 48 hours) showed significant cytotoxicity against multiple cancer cell lines (U2OS, SKOV3, Saos-2, MDA-MB-231) and also exhibited notable cytotoxicity in p53-deficient cancer cells (SKOV3 and Saos-2) [4].
In vivo	Soyasapogenol A (15 mg/kg, intragastric administration) significantly inhibited the growth of tumor volume in the subcutaneous parazacco spilurus subsp. spilurus xenograft model of SKOV-3 cells and effectively reduced lung metastasis of tumors in the tail vein parazacco spilurus subsp. spilurus xenograft model of SKOV-3 cells [4].

Chemical Properties

Molecular Weight	474.72
Formula	C₃₀H₅₀O₄
Cas No.	508-01-0
Smiles	[H][C@@]12CC(C)(C)[C@@H](O)[C@@H](O)[C@]1(C)CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)[C@](C)(CO)[C@]3([H])CC[C@@]12C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (168.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1065 mL	10.5325 mL	21.0650 mL	105.3252 mL
5 mM	0.4213 mL	2.1065 mL	4.2130 mL	21.0650 mL
10 mM	0.2107 mL	1.0533 mL	2.1065 mL	10.5325 mL
20 mM	0.1053 mL	0.5266 mL	1.0533 mL	5.2663 mL
50 mM	0.0421 mL	0.2107 mL	0.4213 mL	2.1065 mL
100 mM	0.0211 mL	0.1053 mL	0.2107 mL	1.0533 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc