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Ethaverine hydrochloride

Name: Ethaverine hydrochloride
Brand: TargetMol
SKU: T0369
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0369Cas No. 985-13-7

Alias Papetherine, Ethaquin, Consenil

Ethaverine hydrochloride is a homologue of papaverine and is used as a vasodilator and antispasmodic.[2]

Ethaverine hydrochloride

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Purity: 99.90%

Catalog No. T0369Alias Papetherine, Ethaquin, ConsenilCas No. 985-13-7

Ethaverine hydrochloride is a homologue of papaverine and is used as a vasodilator and antispasmodic.[2]

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	In Stock	In Stock
5 mg	$57	In Stock	In Stock
10 mg	$103	In Stock	In Stock
25 mg	$177	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$377	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC MS HNMR

Product Introduction

Ethaverine hydrochloride AI Summary

Ethaverine hydrochloride exhibits a diverse range of bioactivities, demonstrating potency in several biological assays. It functions as an enhancer of SMN2 splice variant expression and inhibits multiple targets, including ROR gamma transcriptional activity, the ERK signaling pathway, 15-human lipoxygenase 2, Polymerase Kappa, USP1/UAF1, human tyrosyl-DNA phosphodiesterase 1 (TDP1), as well as both Vaccinia Orthopoxvirus and Marburg Virus entry into cells. Additionally, this compound effectively blocks Ebola Virus entry. Specifically, Ethaverine hydrochloride inhibits sodium fluorescein uptake in both OATP1B3-transfected CHO cells and OATP1B1-transfected CHO cells at a concentration of 10 µM, with respective inhibition percentages of 156.16% and 524.92%. It also exhibits moderate activity in reducing the viability of SARS-CoV-2 infected Vero E6 cells, with an inhibition index of 0.4908. Moreover, the compound shows strong antiviral activity against SARS-CoV-2, evidenced by a 99.42% inhibition of virus-induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours and a low IC50 value of 640.0 nM. It has a selectivity index of 17.0, suggesting a favorable therapeutic profile. However, it shows 11.3% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. Despite this, the assay results for VERO-6 cells indicated an inhibition percentage of -0.08% under the tested conditions. Overall, Ethaverine hydrochloride is a multifaceted agent with significant potential across various biological and antiviral applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ethaverine hydrochloride is a homologue of papaverine and is used as a vasodilator and antispasmodic.[2]
In vitro	METHODS: The inhibitory effect of ethaverine on dopamine content in PC12 cells was studied. RESULTS Ethaverine reduced dopamine content in PC12 cells in a concentration-dependent manner. At a concentration of 1.0 μM, dopamine content was inhibited by 33.6% within 24-48 hours. The IC50 value of ethaverine was 1.4 μM. 2.0 μM ethaverine reduced dopamine content after 6 hours of action. Tyrosine hydroxylase (TH) was inhibited after 6 hours of ethaverine treatment in PC12 cells, and the activity remained at a reduced level until 36 hours (the inhibition rate was 12-22% at 2.0 μM). [1] Ethaverine (10 μM) treatment in PC12 cells reduces catecholamine secretion by blocking L-type voltage-sensitive Ca2+ channels. [2]
In vivo	METHODS: In a short-term experiment on 11 guinea pigs, the effect of Ethaverine hydrochloride on cochlear microcirculation was observed (2/5 and /10 mg/kg, i.v) for 10 minutes. In these experiments, intracochlear PO2, intracochlear potential (EP), cochlear microphonic (CM) potential, and blood pressure (BP) were recorded. Intracochlear PO2 was measured polarographically in the mid-level using gold electrodes. RESULTS Ethaverine hydrochloride at doses of 5 and 10 mg/kg caused a significant increase in intracochlear PO2 for 35 to 90 minutes, even with a temporary decrease in blood pressure. At the same time, this improvement in cochlear microcirculation was observed to coincide with an increase in CM potential. The decrease in EP may be the result of a decrease in blood pressure and a direct effect of Ethaverine hydrochloride on EP production. [3]
Synonyms	Papetherine, Ethaquin, Consenil

Chemical Properties

Molecular Weight	431.96
Formula	C₂₄H₃₀ClNO₄
Cas No.	985-13-7
Smiles	CCOc1c(OCC)cc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1.Cl
Relative Density.	1.104g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (231.5 mM), Sonication is recommended.

DMSO: 16 mg/mL (37.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3150 mL	11.5751 mL	23.1503 mL	115.7515 mL
5 mM	0.4630 mL	2.3150 mL	4.6301 mL	23.1503 mL
10 mM	0.2315 mL	1.1575 mL	2.3150 mL	11.5751 mL
20 mM	0.1158 mL	0.5788 mL	1.1575 mL	5.7876 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0463 mL	0.2315 mL	0.4630 mL	2.3150 mL
100 mM	0.0232 mL	0.1158 mL	0.2315 mL	1.1575 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc