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2-Hydroxysaclofen

Name: 2-Hydroxysaclofen
Brand: TargetMol
SKU: T22495
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22495Cas No. 117354-64-0

2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B receptor antagonist that effectively abolishes nicotine-induced hypolocomotor effects, enhances antinociceptive responses, and stimulates luteinizing hormone secretion in female rats, making it a valuable pharmacological probe for investigating GABAB receptor–mediated neuroendocrine regulation and behavioral pharmacology.

2-Hydroxysaclofen

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Purity: 98.56%

Catalog No. T22495Cas No. 117354-64-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	-	In Stock
5 mg	$219	-	In Stock
10 mg	$326	-	In Stock
25 mg	$546	-	In Stock
50 mg	$778	-	In Stock
100 mg	$1,060	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.56%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vivo

In male Swiss Webster mice, intraperitoneal (IP) administration of 2-Hydroxysaclofen (0.25-1 mg/kg) modulates the acute effects of nicotine. At a dose of 1 mg/kg, it abolishes nicotine-induced hypolocomotion while enhancing its antinociceptive effects. In male Wistar rats, IP administration (0.3-3 mg/kg) antagonizes the ability of Baclofen to alter the discriminative stimulus effects of d-amphetamine. Furthermore, in estrogen-primed ovariectomized female rats, intracerebroventricular (ICV) injection (50-100 ug/mL) leads to an elevation in serum Luteinizing Hormone (LH) concentrations, with peak levels observed 10 minutes post-injection [1][2][3].

Chemical Properties

Molecular Weight	265.71
Formula	C₉H₁₂ClNO₄S
Cas No.	117354-64-0
Smiles	O=S(=O)(O)CC(O)(C1=CC=C(Cl)C=C1)CN
Relative Density.	1.551 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1M NaOH: 25 mg/mL (94.09 mM), Sonication is recommended.

H2O: 40 mg/mL (150.54 mM), when pH is adjusted to 11 with 1 M NaOH. Sonication is recommmended.

1eq. NaOH: 100 mM, Sonication is recommended.

Solution Preparation Table

1M NaOH/1eq. NaOH/H2O

	1mg	5mg	10mg	50mg
1 mM	3.7635 mL	18.8175 mL	37.6350 mL	188.1751 mL
5 mM	0.7527 mL	3.7635 mL	7.5270 mL	37.6350 mL
10 mM	0.3764 mL	1.8818 mL	3.7635 mL	18.8175 mL
20 mM	0.1882 mL	0.9409 mL	1.8818 mL	9.4088 mL
50 mM	0.0753 mL	0.3764 mL	0.7527 mL	3.7635 mL

1eq. NaOH/H2O

	1mg	5mg	10mg	50mg
100 mM	0.0376 mL	0.1882 mL	0.3764 mL	1.8818 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc