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2-Hydroxysaclofen

Name: 2-Hydroxysaclofen
Brand: TargetMol
SKU: T22495
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22495Cas No. 117354-64-0

2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B receptor antagonist that effectively abolishes nicotine-induced hypolocomotor effects, enhances antinociceptive responses, and stimulates luteinizing hormone secretion in female rats, making it a valuable pharmacological probe for investigating GABAB receptor–mediated neuroendocrine regulation and behavioral pharmacology.

2-Hydroxysaclofen

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Purity: 98.56%

Catalog No. T22495Cas No. 117354-64-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	-	In Stock
5 mg	$219	-	In Stock
10 mg	$326	-	In Stock
25 mg	$546	-	In Stock
50 mg	$778	-	In Stock
100 mg	$1,060	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.56%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vivo

In male Swiss Webster mice, intraperitoneal (IP) administration of 2-Hydroxysaclofen (0.25-1 mg/kg) modulates the acute effects of nicotine. At a dose of 1 mg/kg, it abolishes nicotine-induced hypolocomotion while enhancing its antinociceptive effects. In male Wistar rats, IP administration (0.3-3 mg/kg) antagonizes the ability of Baclofen to alter the discriminative stimulus effects of d-amphetamine. Furthermore, in estrogen-primed ovariectomized female rats, intracerebroventricular (ICV) injection (50-100 ug/mL) leads to an elevation in serum Luteinizing Hormone (LH) concentrations, with peak levels observed 10 minutes post-injection [1][2][3].

Chemical Properties

Molecular Weight	265.71
Formula	C₉H₁₂ClNO₄S
Cas No.	117354-64-0
Smiles	O=S(=O)(O)CC(O)(C1=CC=C(Cl)C=C1)CN
Relative Density.	1.551 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1M NaOH: 25 mg/mL (94.09 mM), Sonication is recommended.

H2O: 40 mg/mL (150.54 mM), when pH is adjusted to 11 with 1 M NaOH. Sonication is recommmended.

1eq. NaOH: 100 mM, Sonication is recommended.

Solution Preparation Table

1M NaOH/1eq. NaOH/H2O

	1mg	5mg	10mg	50mg
1 mM	3.7635 mL	18.8175 mL	37.6350 mL	188.1751 mL
5 mM	0.7527 mL	3.7635 mL	7.5270 mL	37.6350 mL
10 mM	0.3764 mL	1.8818 mL	3.7635 mL	18.8175 mL
20 mM	0.1882 mL	0.9409 mL	1.8818 mL	9.4088 mL
50 mM	0.0753 mL	0.3764 mL	0.7527 mL	3.7635 mL

1eq. NaOH/H2O

	1mg	5mg	10mg	50mg
100 mM	0.0376 mL	0.1882 mL	0.3764 mL	1.8818 mL

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In Vivo Formulation Calculator (Clear solution)

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

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Dose Conversion

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