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CFT8634

Name: CFT8634
Brand: TargetMol
SKU: T73425
Rating: 4.5 (1 reviews)

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Catalog No. T73425Cas No. 2704617-96-7

CFT8634 is an orally active and selective degrader targeting BRD9, with effects on the proliferation of SMARCB1-deficient cancer cell lines. CFT8634 induces the formation of a ternary complex with BRD9 and E3 ligase, inducing BRD9 ubiquitination and subsequent degradation by the proteasome.

CFT8634

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Catalog No. T73425Cas No. 2704617-96-7

Pack Size	Price	Availability	Quantity
25 mg	$6,428	10-14 weeks

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	710.79
Formula	C₃₇H₄₅F₃N₆O₅
Cas No.	2704617-96-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (140.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4069 mL	7.0344 mL	14.0689 mL	70.3443 mL
5 mM	0.2814 mL	1.4069 mL	2.8138 mL	14.0689 mL
10 mM	0.1407 mL	0.7034 mL	1.4069 mL	7.0344 mL
20 mM	0.0703 mL	0.3517 mL	0.7034 mL	3.5172 mL
50 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4069 mL
100 mM	0.0141 mL	0.0703 mL	0.1407 mL	0.7034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc