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2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid
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Catalog No. T38224Cas No. 24967-27-9
2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid is a pan-sialidase (neuraminidase, NEU) inhibitor with inhibitory activity against sialidases 1–4, with an IC50 of 43–143 μM, and also exhibits inhibitory activity against various influenza viruses.
2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid
😃Good
Catalog No. T38224Cas No. 24967-27-9
2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid is a pan-sialidase (neuraminidase, NEU) inhibitor with inhibitory activity against sialidases 1–4, with an IC50 of 43–143 μM, and also exhibits inhibitory activity against various influenza viruses.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $522 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid is a pan-sialidase (neuraminidase, NEU) inhibitor with inhibitory activity against sialidases 1–4, with an IC50 of 43–143 μM, and also exhibits inhibitory activity against various influenza viruses. |
| In vitro | Methods: To evaluate the effect on sialidase activity in pancreatic β-cells, INS-1D cells were used, and in vitro enzymatic activity was measured using the substrate 4MU-Neu5Ac (2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid). Results: N-acetyl-2,3-dehydro-2-deoxyneuraminic acid (DANA / Neu5Ac2en) significantly inhibited sialidase activity in INS-1D cells at concentrations ranging from 10 to 100 μM in a dose-dependent manner [1]. |
| In vivo | Methods: A mouse model of pulmonary fibrosis was established using bleomycin. Starting on day 10 after bleomycin administration, mice were intraperitoneally injected with 2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid (DANA) at a dose of 10 mg/kg daily. Treatment continued until day 21, at which point the animals were euthanized for tissue analysis. Results: Inhibition of sialidase activity starting on day 10 after bleomycin administration significantly attenuated pulmonary fibrosis, suggesting that DANA exerts anti-fibrotic effects.[1] |
| Molecular Weight | 291.26 |
| Formula | C11H17NO8 |
| Cas No. | 24967-27-9 |
| Smiles | [C@H]([C@@H](CO)O)(O)[C@]1([C@H](NC(C)=O)[C@@H](O)C=C(C(O)=O)O1)[H] |
| Relative Density. | 1.58 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMF: < 1 mg/ml (insoluble), Sonication is recommended. DMSO: 1 mg/mL (3.43 mM), Sonication is recommended. PBS (pH 7.2): 10 mg/mL (34.33 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/PBS (pH 7.2)
PBS (pH 7.2)
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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