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2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid
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Catalog No. T38224Cas No. 24967-27-9
2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid is a pan-sialidase (neuraminidase, NEU) inhibitor with inhibitory activity against sialidases 1–4, with an IC50 of 43–143 μM, and also exhibits inhibitory activity against various influenza viruses.
2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid
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Catalog No. T38224Cas No. 24967-27-9
2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid is a pan-sialidase (neuraminidase, NEU) inhibitor with inhibitory activity against sialidases 1–4, with an IC50 of 43–143 μM, and also exhibits inhibitory activity against various influenza viruses.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $522 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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| Description | 2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid is a pan-sialidase (neuraminidase, NEU) inhibitor with inhibitory activity against sialidases 1–4, with an IC50 of 43–143 μM, and also exhibits inhibitory activity against various influenza viruses. |
| In vitro | Methods: To evaluate the effect on sialidase activity in pancreatic β-cells, INS-1D cells were used, and in vitro enzymatic activity was measured using the substrate 4MU-Neu5Ac (2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid). Results: N-acetyl-2,3-dehydro-2-deoxyneuraminic acid (DANA / Neu5Ac2en) significantly inhibited sialidase activity in INS-1D cells at concentrations ranging from 10 to 100 μM in a dose-dependent manner [1]. |
| In vivo | Methods: A mouse model of pulmonary fibrosis was established using bleomycin. Starting on day 10 after bleomycin administration, mice were intraperitoneally injected with 2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid (DANA) at a dose of 10 mg/kg daily. Treatment continued until day 21, at which point the animals were euthanized for tissue analysis. Results: Inhibition of sialidase activity starting on day 10 after bleomycin administration significantly attenuated pulmonary fibrosis, suggesting that DANA exerts anti-fibrotic effects.[1] |
| Molecular Weight | 291.26 |
| Formula | C11H17NO8 |
| Cas No. | 24967-27-9 |
| Smiles | [C@H]([C@@H](CO)O)(O)[C@]1([C@H](NC(C)=O)[C@@H](O)C=C(C(O)=O)O1)[H] |
| Relative Density. | 1.58 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMF: < 1 mg/ml (insoluble), Sonication is recommended. DMSO: 1 mg/mL (3.43 mM), Sonication is recommended. PBS (pH 7.2): 10 mg/mL (34.33 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/PBS (pH 7.2)
PBS (pH 7.2)
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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