Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

TRPC6-IN-3

Name: TRPC6-IN-3
Brand: TargetMol
SKU: T62272
Rating: 4.5 (1 reviews)

(Synonyms: Apecotrep, (4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(5-(4-fluorophenoxy)-4-methoxypyridin-2-yl)methanone) Copy Product Info

🥰Excellent

Synonyms: Apecotrep, (4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(5-(4-fluorophenoxy)-4-methoxypyridin-2-yl)methanone

Catalog No. T62272 Copy Product Info

🥰Excellent

TRPC6-IN-3 ((4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(5-(4-fluorophenoxy)-4-methoxypyridin-2-yl)methanone) is an orally active inhibitor of the transient receptor potential canonical 6 (TRPC6) ion channel. It regulates intracellular calcium concentration and influences membrane potential by modulating the flux of cations, including calcium and sodium ions. TRPC6-IN-3 can be used for research on respiratory system-related diseases.

Cas No. 2311863-36-0

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	TRPC6-IN-3 ((4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(5-(4-fluorophenoxy)-4-methoxypyridin-2-yl)methanone) is an orally active inhibitor of the transient receptor potential canonical 6 (TRPC6) ion channel. It regulates intracellular calcium concentration and influences membrane potential by modulating the flux of cations, including calcium and sodium ions. TRPC6-IN-3 can be used for research on respiratory system-related diseases.
In vivo	Method: In a mouse model, TRPC6-IN-3 was orally administered at doses of 1-10 mg/kg at 12 hours and 2 hours prior to LPS challenge, establishing an LPS-induced mouse model. Result: TRPC6-IN-3 inhibited LPS-induced vascular leakage and reduced the accumulation of bronchoalveolar lavage fluid (BALF) protein in mice [1]. Method: In a mouse model infected with H1N1 virus, TRPC6-IN-3 was orally administered at a dose of 3 mg/kg once daily for 4 consecutive days. Result: TRPC6-IN-3 reduced H1N1 virus-induced vascular leakage [1].
Synonyms	Apecotrep, (4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(5-(4-fluorophenoxy)-4-methoxypyridin-2-yl)methanone

Chemical Properties

Molecular Weight	423.44
Formula	C₂₂H₂₂FN₅O₃
Cas No.	2311863-36-0
Smiles	O=C(C1=NC=C(OC2=CC=C(F)C=C2)C(OC)=C1)N3CCC(C4=NN=C(N)C=C4)CC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (236.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3616 mL	11.8080 mL	23.6161 mL	118.0805 mL
5 mM	0.4723 mL	2.3616 mL	4.7232 mL	23.6161 mL
10 mM	0.2362 mL	1.1808 mL	2.3616 mL	11.8080 mL
20 mM	0.1181 mL	0.5904 mL	1.1808 mL	5.9040 mL
50 mM	0.0472 mL	0.2362 mL	0.4723 mL	2.3616 mL
100 mM	0.0236 mL	0.1181 mL	0.2362 mL	1.1808 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: TRPC6-IN-3 chemical structure | TRPC6-IN-3 in vivo | TRPC6-IN-3 formula | TRPC6-IN-3 molecular weight