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DETA NONOate

Name: DETA NONOate
Brand: TargetMol
SKU: T36033
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36033Cas No. 146724-94-9

Alias NOC-18, Diethylamine NONOate

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infected wounds.

DETA NONOate

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Purity: 99.60%

Catalog No. T36033Alias NOC-18, Diethylamine NONOateCas No. 146724-94-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$61	-	In Stock
10 mg	$87	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.60%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infected wounds.
In vitro	By reducing the expression of glycopeptidolipids (GPL) in M. abscessus subspecies abscessus (Mab), DETA NONOate (100 μM; 16 h) induces the growth of nontuberculous mycobacteria (NTM) complex in the R morphotype[3].
In vivo	DETA NONOate (15-150 μg/rat, intracerebroventricular injection, once) activates nociceptors in the formalin model in rats[4] and, at 1 µM, reduces ischemia or ischemia/reperfusion-induced mitochondrial damage in the heart while preventing apoptotic cell death[2].
Synonyms	NOC-18, Diethylamine NONOate

Chemical Properties

Molecular Weight	163.18
Formula	C₄H₁₃N₅O₂
Cas No.	146724-94-9
Smiles	ON(N=O)N(CCN)CCN

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

aqueous buffers: >100 mg/mL, Sonication is recommended.

H2O: 30 mg/mL (183.85 mM), when pH is adjusted to 9 with NaOH. Sonication is recommended.

1M NaOH: 120 mg/mL (735.38 mM)

DMSO: <1 mg/mL (Insoluble)

Solution Preparation Table

H2O/1M NaOH

	1mg	5mg	10mg	50mg
1 mM	6.1282 mL	30.6410 mL	61.2820 mL	306.4101 mL
5 mM	1.2256 mL	6.1282 mL	12.2564 mL	61.2820 mL
10 mM	0.6128 mL	3.0641 mL	6.1282 mL	30.6410 mL
20 mM	0.3064 mL	1.5321 mL	3.0641 mL	15.3205 mL
50 mM	0.1226 mL	0.6128 mL	1.2256 mL	6.1282 mL
100 mM	0.0613 mL	0.3064 mL	0.6128 mL	3.0641 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc