Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anti-inflammatory agent 40 is a promising, orally-active compound with anti-malarial and anti-inflammatory properties. It effectively inhibits carrageenan-induced paw swelling in vivo.
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Description | Anti-inflammatory agent 40 is a promising, orally-active compound with anti-malarial and anti-inflammatory properties. It effectively inhibits carrageenan-induced paw swelling in vivo. |
In vitro | Anti-inflammatory agent 40 (compound 5p) exhibits inhibitory effects on both chloroquine-sensitive and resistant strains of Plasmodium falciparum, with an IC50 value of 1.47 μM against the chloroquine-sensitive P. falciparum strain (Pf 3D7). Additionally, this agent suppresses lipopolysaccharide-induced activation of MAP kinases and reduces the expression of phosphorylated ERK1/2 (Thr202/Tyr204) and JNK1/2 in THP-1 monocytes [1]. |
In vivo | Anti-inflammatory agent 40 (compound 5p) demonstrated inhibition of carrageenan-induced paw swelling in Swiss mice when administered 1 hour before carrageenan injection at doses of 25, 50, and 100 mg/kg, with swelling reductions observed at 4 and 6 hours post-injection. At 25 mg/kg, the inhibition rates were 61% and 56% at 4 and 6 hours, respectively. At 50 mg/kg, the inhibition rates further increased to 73% and 65% at the corresponding time points. Additionally, Agent 40 exhibited favorable pharmacokinetic properties with a Cmax of 110.37±11.92 ng/mL, Tmax of 0.25±0.0 h, AUC of 86.91±16.86 h.ng/mL, and T1/2 of 0.87±0.15 h, making it a promising candidate for future drug discovery optimization [1]. |
Molecular Weight | 547.43 |
Formula | C30H24Cl2N2O4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Anti-inflammatory agent 40 Microbiology/Virology Parasite inhibitor inhibit