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Masofaniten
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Catalog No. T72985Cas No. 2416716-62-4
Alias EPI-7386, EPI7386, Androgen receptor-IN-2
Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers.
Masofaniten
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Purity: 98.66%
Catalog No. T72985Alias EPI-7386, EPI7386, Androgen receptor-IN-2Cas No. 2416716-62-4
Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $132 | In Stock | In Stock | |
| 5 mg | $328 | In Stock | In Stock | |
| 10 mg | $579 | In Stock | In Stock | |
| 25 mg | $1,190 | In Stock | In Stock | |
| 50 mg | $1,980 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $389 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.66%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers. |
| Targets&IC50 | LNCaP95 cells:3.78 μM, Androgen receptor:535 nM, LNCaP cells:0.44 μM |
| In vitro | In the androgen-induced PSA-luciferase assay, Masofaniten effectively inhibited androgen binding to the androgen receptor with an IC50 value of 535 nM. In LNCaP and LNCaP95 cells, Masofaniten showed an inhibitory effect on cell proliferation with IC50 values of 0.44 μM and 3.78 μM, respectively. In addition, Masofaniten showed good metabolic stability in liver microsomes with a half-life of more than 120 min, while the half-life in hepatocytes was more than 360 min. [1] |
| In vivo | Masofaniten was able to partially inhibit tumor growth in NCG mice bearing LNCaP tumors after oral administration at a dose of 60 mg/kg. In male CD-1 mice, a single oral administration of Masofaniten at 5 mg/kg exhibited a half-life of 8.1 hours, a maximum concentration (Cmax) of 2673.3 ng/mL, and a bioavailability (F (%)) of 33.6. [1] |
| Synonyms | EPI-7386, EPI7386, Androgen receptor-IN-2 |
| Molecular Weight | 535.44 |
| Formula | C24H24Cl2N4O4S |
| Cas No. | 2416716-62-4 |
| Smiles | N#CC1=CC(=CC(Cl)=C1OCCCl)C(C2=CC=C(OCC3=NC(=NC=C3)NS(=O)(=O)C)C=C2)(C)C |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (74.7 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 4 mg/mL (7.47 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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