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Masofaniten (Synonyms: EPI-7386, EPI7386, Androgen receptor-IN-2)

Name: Masofaniten
Brand: TargetMol
SKU: T72985
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T72985 Copy Product Info

Purity: 98.66%

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Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers.

Masofaniten

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Catalog No. T72985

Synonyms EPI-7386, EPI7386, Androgen receptor-IN-2

Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers.

Cas No. 2416716-62-4

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Pack Size	Price	USA Stock	Global Stock
1 mg	$132	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$579	In Stock	In Stock
25 mg	$1,190	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$389	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.66%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers.
Targets&IC50	LNCaP95 cells:3.78 μM, Androgen receptor:535 nM, LNCaP cells:0.44 μM
In vitro	In the androgen-induced PSA-luciferase assay, Masofaniten effectively inhibited androgen binding to the androgen receptor with an IC50 value of 535 nM. In LNCaP and LNCaP95 cells, Masofaniten showed an inhibitory effect on cell proliferation with IC50 values of 0.44 μM and 3.78 μM, respectively. In addition, Masofaniten showed good metabolic stability in liver microsomes with a half-life of more than 120 min, while the half-life in hepatocytes was more than 360 min. [1]
In vivo	Masofaniten was able to partially inhibit tumor growth in NCG mice bearing LNCaP tumors after oral administration at a dose of 60 mg/kg. In male CD-1 mice, a single oral administration of Masofaniten at 5 mg/kg exhibited a half-life of 8.1 hours, a maximum concentration (Cmax) of 2673.3 ng/mL, and a bioavailability (F (%)) of 33.6. [1]
Synonyms	EPI-7386, EPI7386, Androgen receptor-IN-2

Chemical Properties

Molecular Weight	535.44
Formula	C₂₄H₂₄Cl₂N₄O₄S
Cas No.	2416716-62-4
Smiles	N#CC1=CC(=CC(Cl)=C1OCCCl)C(C2=CC=C(OCC3=NC(=NC=C3)NS(=O)(=O)C)C=C2)(C)C

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (74.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 4 mg/mL (7.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8676 mL	9.3381 mL	18.6762 mL	93.3811 mL
5 mM	0.3735 mL	1.8676 mL	3.7352 mL	18.6762 mL
10 mM	0.1868 mL	0.9338 mL	1.8676 mL	9.3381 mL
20 mM	0.0934 mL	0.4669 mL	0.9338 mL	4.6691 mL
50 mM	0.0374 mL	0.1868 mL	0.3735 mL	1.8676 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc