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Gypenoside LI

Name: Gypenoside LI
Brand: TargetMol
SKU: TN4177
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4177Cas No. 94987-10-7

Gypenoside LI is a natural product with anticancer activity that generates ROS, downregulates procaspase-8 and MMP-2/9, inhibits Wnt/β-catenin signaling, and induces cell cycle arrest and apoptosis.

Gypenoside LI

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Purity: 99.56%

Catalog No. TN4177Cas No. 94987-10-7

Gypenoside LI is a natural product with anticancer activity that generates ROS, downregulates procaspase-8 and MMP-2/9, inhibits Wnt/β-catenin signaling, and induces cell cycle arrest and apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$263	-	In Stock
10 mg	$428	-	In Stock
25 mg	$698	-	In Stock
50 mg	$993	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Gypenoside LI is a natural product with anticancer activity that generates ROS, downregulates procaspase-8 and MMP-2/9, inhibits Wnt/β-catenin signaling, and induces cell cycle arrest and apoptosis.
In vitro	Gypenoside LI (0-80 μM) dose-dependently inhibited the activity of A549 cells, inducing G2/M phase cell cycle arrest and apoptosis in these cells [1]. Gypenoside LI (75 and 29.71 μg/mL) could induce endogenous apoptosis in cells, accompanied by S-phase cell cycle arrest. Gypenoside LI reduced the colony-forming ability of melanoma cells by inhibiting the Wnt/β-catenin signaling pathway [2].

Chemical Properties

Molecular Weight	801.02
Formula	C₄₂H₇₂O₁₄
Cas No.	94987-10-7
Smiles	[H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)C[C@@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@]3([H])CC[C@@]21C)[C@](C)(O)CCC=C(C)C
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (99.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2484 mL	6.2420 mL	12.4841 mL	62.4204 mL
5 mM	0.2497 mL	1.2484 mL	2.4968 mL	12.4841 mL
10 mM	0.1248 mL	0.6242 mL	1.2484 mL	6.2420 mL
20 mM	0.0624 mL	0.3121 mL	0.6242 mL	3.1210 mL
50 mM	0.0250 mL	0.1248 mL	0.2497 mL	1.2484 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc