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Cyclic GMP
Catalog No. TN9056 Copy Product Info
Purity: 99.99%
🥰Excellent
Cyclic GMP (cGMP) belongs to the class of endogenous metabolites and is a pivotal intracellular second messenger that mediates extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). The effects of Cyclic GMP are primarily executed through three main target groups: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). Cyclic GMP is capable of inhibiting platelet adhesion and aggregation and participates in enhancing antiviral immune responses.
Cyclic GMP
Copy Product Info🥰Excellent
Catalog No. TN9056
Cyclic GMP (cGMP) belongs to the class of endogenous metabolites and is a pivotal intracellular second messenger that mediates extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). The effects of Cyclic GMP are primarily executed through three main target groups: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). Cyclic GMP is capable of inhibiting platelet adhesion and aggregation and participates in enhancing antiviral immune responses.
Cas No. 7665-99-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $45 | - | In Stock | |
| 5 mg | $106 | - | In Stock | |
| 10 mg | $163 | - | In Stock | |
| 25 mg | $328 | - | In Stock | |
| 50 mg | $463 | - | In Stock | |
| 100 mg | $648 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.99%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cyclic GMP (cGMP) belongs to the class of endogenous metabolites and is a pivotal intracellular second messenger that mediates extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). The effects of Cyclic GMP are primarily executed through three main target groups: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). Cyclic GMP is capable of inhibiting platelet adhesion and aggregation and participates in enhancing antiviral immune responses. |
| In vitro | In vitro studies on cardiac cells show that Cyclic GMP (1 microM) accumulation stimulated by ACh acts synergistically with Isoprenaline to activate cGMP-stimulated phosphodiesterases. This process inhibits cAMP-induced inward calcium current (ICa) and shortens action potentials. Additionally, its conjugate cGAMP induces IRF3 phosphorylation and nuclear translocation[1]. |
| In vivo | In anesthetized rat models, Cyclic GMP has been demonstrated to effectively prevent renal platelet accumulation following ischemia-reperfusion, a protective effect not shared by cAMP, indicating its specificity in maintaining microcirculatory stability[1]. |
| Molecular Weight | 345.21 |
| Formula | C10H12N5O7P |
| Cas No. | 7665-99-8 |
| Smiles | O=C1C2=C(N(C=N2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H])NC(N)=N1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
| Solubility Information | H2O: 4.00 mg/mL (11.59 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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