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Antioxidant agent-22
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Catalog No. T217890 Copy Product Info
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Antioxidant agent-22 is a tetracyclohexaphosphazene compound derived from paraben. It exhibits antioxidant, anti-inflammatory, and pro-apoptotic (apoptosis) activities. This compound significantly upregulates the expression of CAT, SOD, caspase-3, and IL-6 while inhibiting GSH and IL-1β and reducing the levels of BCL-2 and BAX. Antioxidant agent-22 is applicable in cancer-related research, such as studies on lung cancer.
Antioxidant agent-22
Cas No. 2996086-75-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antioxidant agent-22 is a tetracyclohexaphosphazene compound derived from paraben. It exhibits antioxidant, anti-inflammatory, and pro-apoptotic (apoptosis) activities. This compound significantly upregulates the expression of CAT, SOD, caspase-3, and IL-6 while inhibiting GSH and IL-1β and reducing the levels of BCL-2 and BAX. Antioxidant agent-22 is applicable in cancer-related research, such as studies on lung cancer. |
| In vitro | Antioxidant agent-22 (Compound 5) exhibits cytotoxic activity against human lung adenocarcinoma cells A549 with an IC50 of 12.650 μM and shows very low toxicity to human lung fibroblasts MRC-5 at concentrations ranging from 1.56 to 100 μM. It regulates the expression of antioxidant genes (CAT, GSS, SOD), anti-inflammatory gene (IL-6), and Caspase-3 while reducing the expression of apoptosis-related genes (BCL-2, BAX) in A549 cells. The compound exhibits antioxidant activity by reducing GSH levels, anti-inflammatory activity by lowering IL-1β levels, and pro-apoptotic activity by increasing Caspase-3 levels in human lung adenocarcinoma A549 cells. |
| Molecular Weight | 719.69 |
| Formula | C32H48N7O6P3 |
| Cas No. | 2996086-75-8 |
| Smiles | O=C(OCCCC)C1=CC=C(OP2(=NP34=NCCCN4CCCCN5CCCN=P5(N2)N3)OC6=CC=C(C=C6)C(=O)OCCCC)C=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Antioxidant agent-22 in vitro | Antioxidant agent-22 formula | Antioxidant agent-22 molecular weight
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