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Desglymidodrine

Name: Desglymidodrine
Brand: TargetMol
SKU: T31388L
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31388LCas No. 3600-87-1

Alias ST1059, ST 1059

Desglymidodrine (ST 1059) is a selective α1-adrenoceptor agonist and an active metabolite of Midodrine. It is a vasoconstrictor that can be used for cardiovascular research and neurocardiogenic syncope.

Desglymidodrine

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Purity: 99.56%

Catalog No. T31388LAlias ST1059, ST 1059Cas No. 3600-87-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	-	In Stock
5 mg	$77	-	In Stock
10 mg	$123	-	In Stock
25 mg	$222	-	In Stock
50 mg	$313	-	In Stock
100 mg	$467	-	In Stock
200 mg	$669	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.56%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Desglymidodrine (ST 1059) is a selective α1-adrenoceptor agonist and an active metabolite of Midodrine. It is a vasoconstrictor that can be used for cardiovascular research and neurocardiogenic syncope.
Targets&IC50	α1D-adrenoceptor (rat):5.78 (pKi), α2A-adrenoceptor (human):5.83 (pKi), α1A-adrenoceptor (rat):5.89 (pKi), α1B-adrenoceptor (rat):5.16 (pKi)
In vitro	Desglymidodrine affects venoconstriction over a concentration range of 1-1000 μM, with a pD2 value of 4.64 (-log mol/L) in isolated canine femoral veins and 4.48 (-log mol/L) in isolated human saphenous veins. [1] Desglymidodrine binds to α1A, α1B, and α1D adrenergic receptors in rats and α2A adrenergic receptors in humans, corresponding to pKi values of 5.89, 5.16, 5.78, and 5.83, respectively. [2]
Synonyms	ST1059, ST 1059

Chemical Properties

Molecular Weight	197.23
Formula	C₁₀H₁₅NO₃
Cas No.	3600-87-1
Smiles	OC(C1=CC(OC)=CC=C1OC)CN
Relative Density.	1.145 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40.00 mg/mL (202.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0702 mL	25.3511 mL	50.7022 mL	253.5111 mL
5 mM	1.0140 mL	5.0702 mL	10.1404 mL	50.7022 mL
10 mM	0.5070 mL	2.5351 mL	5.0702 mL	25.3511 mL
20 mM	0.2535 mL	1.2676 mL	2.5351 mL	12.6756 mL
50 mM	0.1014 mL	0.5070 mL	1.0140 mL	5.0702 mL
100 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc