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Desglymidodrine

Name: Desglymidodrine
Brand: TargetMol
SKU: T31388L
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31388LCas No. 3600-87-1

Alias ST1059, ST 1059

Desglymidodrine (ST 1059) is a selective α1-adrenoceptor agonist and an active metabolite of Midodrine. It is a vasoconstrictor that can be used for cardiovascular research and neurocardiogenic syncope.

Desglymidodrine

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Purity: 99.56%

Catalog No. T31388LAlias ST1059, ST 1059Cas No. 3600-87-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$222	In Stock	In Stock
50 mg	$313	In Stock	In Stock
100 mg	$467	In Stock	In Stock
200 mg	$669	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Desglymidodrine (ST 1059) is a selective α1-adrenoceptor agonist and an active metabolite of Midodrine. It is a vasoconstrictor that can be used for cardiovascular research and neurocardiogenic syncope.
Targets&IC50	α1B-adrenoceptor (rat):5.16 (pKi), α1A-adrenoceptor (rat):5.89 (pKi), α1D-adrenoceptor (rat):5.78 (pKi), α2A-adrenoceptor (human):5.83 (pKi)
In vitro	Desglymidodrine affects venoconstriction over a concentration range of 1-1000 μM, with a pD2 value of 4.64 (-log mol/L) in isolated canine femoral veins and 4.48 (-log mol/L) in isolated human saphenous veins. [1] Desglymidodrine binds to α1A, α1B, and α1D adrenergic receptors in rats and α2A adrenergic receptors in humans, corresponding to pKi values of 5.89, 5.16, 5.78, and 5.83, respectively. [2]
Synonyms	ST1059, ST 1059

Chemical Properties

Molecular Weight	197.23
Formula	C₁₀H₁₅NO₃
Cas No.	3600-87-1
Smiles	OC(C1=CC(OC)=CC=C1OC)CN
Relative Density.	1.145 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (202.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0702 mL	25.3511 mL	50.7022 mL	253.5111 mL
5 mM	1.0140 mL	5.0702 mL	10.1404 mL	50.7022 mL
10 mM	0.5070 mL	2.5351 mL	5.0702 mL	25.3511 mL
20 mM	0.2535 mL	1.2676 mL	2.5351 mL	12.6756 mL
50 mM	0.1014 mL	0.5070 mL	1.0140 mL	5.0702 mL
100 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc