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MitoTEMPOL
🥰Excellent
Catalog No. T35965Cas No. 1101113-39-6
MitoTEMPOL is a mitochondria-targeted antioxidant that prevents septal dysfunction by reversing sepsis-induced decreases in mitochondrial function, activation of protein hydrolysis pathways, and reductions in myosin heavy chain content, as well as eliminating cytokine-induced increases in muscle cell superoxide production and decreases in cell size.
MitoTEMPOL
🥰Excellent
Catalog No. T35965Cas No. 1101113-39-6
MitoTEMPOL is a mitochondria-targeted antioxidant that prevents septal dysfunction by reversing sepsis-induced decreases in mitochondrial function, activation of protein hydrolysis pathways, and reductions in myosin heavy chain content, as well as eliminating cytokine-induced increases in muscle cell superoxide production and decreases in cell size.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $155 | In Stock | |
| 10 mg | $248 | In Stock | |
| 25 mg | $492 | In Stock | |
| 50 mg | $718 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MitoTEMPOL is a mitochondria-targeted antioxidant that prevents septal dysfunction by reversing sepsis-induced decreases in mitochondrial function, activation of protein hydrolysis pathways, and reductions in myosin heavy chain content, as well as eliminating cytokine-induced increases in muscle cell superoxide production and decreases in cell size. |
| In vitro | MitoTEMPOL exhibits mitochondria-targeted antioxidant activity, relying on its reaction with ubiquinol to form the corresponding hydroxylamine, and demonstrates superior membrane-associated reactivity compared to non-targeted piperidine nitroxides. |
| Molecular Weight | 583.56 |
| Formula | C32H42BrNO2P |
| Cas No. | 1101113-39-6 |
| Smiles | [Br-].[O]N1C(C)(C)CC(OCCCCC[P+](C=2C=CC=CC2)(C=3C=CC=CC3)C=4C=CC=CC4)CC1(C)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMF: 40 mg/mL (68.54 mM), Sonication is recommended. PBS (pH 7.2): 10 mg/mL (17.14 mM), Sonication is recommended. DMSO: 40 mg/mL (68.54 mM), Sonication is recommended. Ethanol: 40 mg/mL (68.54 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
PBS (pH 7.2)/DMF/DMSO/Ethanol
DMF/DMSO/Ethanol
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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