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8-Isoprostaglandin F2α

Name: 8-Isoprostaglandin F2α
Brand: TargetMol
SKU: T37164
Price: 172 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37164Cas No. 27415-26-5

Alias 8-iso Prostaglandin F2α

8-Isoprostaglandin F2α is a non-enzymatically generated isoprostane derived from arachidonic acid peroxidation in membrane phospholipids, present in human plasma in both esterified and free acid forms. 8-Isoprostaglandin F2α functions as a weak thromboxane prostanoid receptor agonist in vascular smooth muscle, making it a reliable biomarker of oxidative stress.

8-Isoprostaglandin F2α

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Catalog No. T37164Alias 8-iso Prostaglandin F2αCas No. 27415-26-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$172	-	In Stock
1 mg	$278	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	8-Isoprostaglandin F2α is a non-enzymatically generated isoprostane derived from arachidonic acid peroxidation in membrane phospholipids, present in human plasma in both esterified and free acid forms. 8-Isoprostaglandin F2α functions as a weak thromboxane prostanoid receptor agonist in vascular smooth muscle, making it a reliable biomarker of oxidative stress.
In vivo	In animal models, the infusion of 8-Isoprostaglandin F2α induces renal vasoconstriction and results in a decreased glomerular filtration rate (GFR) [1][2].
Synonyms	8-iso Prostaglandin F2α

Chemical Properties

Molecular Weight	354.48
Formula	C₂₀H₃₄O₅
Cas No.	27415-26-5
Smiles	C(/C=C\CCCC(O)=O)[C@H]1[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C[C@@H]1O
Relative Density.	1.153g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: >100 mg/mL, Sonication is recommended.

PBS (pH 7.2): 3 mg/mL (8.46 mM), Sonication is recommended.

DMSO: 80 mg/mL (225.68 mM), Sonication is recommended.

Ethanol: >100 mg/mL, Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8210 mL	14.1052 mL	28.2103 mL	141.0517 mL
5 mM	0.5642 mL	2.8210 mL	5.6421 mL	28.2103 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2821 mL	1.4105 mL	2.8210 mL	14.1052 mL
20 mM	0.1411 mL	0.7053 mL	1.4105 mL	7.0526 mL
50 mM	0.0564 mL	0.2821 mL	0.5642 mL	2.8210 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	1.4105 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc