CDK2 Protein, Human, Recombinant (E. coli, His)

Catalog No. TMPY-04542U

CDK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is P24941.

CDK2 Protein, Human, Recombinant (E. coli, His)

Catalog No. TMPY-04542U

CDK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is P24941.

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Product Information

Biological Activity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	CDK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is P24941.
Species	Human
Expression System	E. coli
Tag	N-6xHis
Accession Number	P24941
Synonyms	p33(CDK2),cyclin-dependent kinase 2,CDKN2
Construction	Met1-Leu298
Protein Purity	> 90% as determined by SDS-PAGE
Molecular Weight	36.1 kDa (Predicted); 34 kDa (Reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 1mM DTT, 40% Glycerol, pH 8.0.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex, whose activity is restricted to the G1-S phage of the cell cycle, it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit, its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells, such as neurons, thymocytes and endothelial cells.