Powder: -20°C for 3 years | In solvent: -80°C for 1 year
α-Hydroxyglutaric Acid Lithium, converted from glutamate in microorganisms and animals, is an inhibitor of α-ketoglutarate-dependent dioxygenase and 5-methylcytosine hydroxylase, and has an inhibitory effect on ATP synthase and mTOR signaling.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 79.00 | |
10 mg | In stock | $ 127.00 | |
25 mg | In stock | $ 268.00 | |
50 mg | In stock | $ 398.00 | |
100 mg | In stock | $ 583.00 | |
500 mg | In stock | $ 1,230.00 |
Description | α-Hydroxyglutaric Acid Lithium, converted from glutamate in microorganisms and animals, is an inhibitor of α-ketoglutarate-dependent dioxygenase and 5-methylcytosine hydroxylase, and has an inhibitory effect on ATP synthase and mTOR signaling. |
In vitro | α-Hydroxyglutaric Acid Lithium inhibits the activity of multiple histone demethylases. In the active site of histone demethylases, α-Hydroxyglutaric Acid Lithium occupies the same space as α-KG, leading to inhibition of their activity. Additionally, α-Hydroxyglutaric Acid Lithium inhibits the activity of TET 5-methylcytosine hydroxylases[1].Treatment of U-87MG cells with α-Hydroxyglutaric Acid Lithium at concentrations ranging from 10 to 50 mM results in increased levels of HIF-1α and decreased levels of endostatin[1]. |
Synonyms | α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base) |
Molecular Weight | 159.98 |
Formula | C5H6Li2O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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α-Hydroxyglutaric Acid Lithium Metabolism Others PI3K/Akt/mTOR signaling mTOR Endogenous Metabolite Decarboxylase αHydroxyglutaricAcidLithium(2889318Freebase) α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base) inhibitor inhibit