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Nebentan potassium

Name: Nebentan potassium
Brand: TargetMol
SKU: T36008
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36008Cas No. 342005-82-7

Alias YM598

Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases.

Nebentan potassium

🥰Excellent

Purity: 99.05%

Catalog No. T36008Alias YM598Cas No. 342005-82-7

Pack Size	Price	Availability
1 mg	$50	In Stock
2 mg	$74	In Stock
5 mg	$119	In Stock
10 mg	$197	In Stock
25 mg	$347	In Stock
50 mg	$557	In Stock
100 mg	$756	In Stock
200 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$143	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.05%

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COA HNMR IC LCMS

Product Introduction

Bioactivity

Description	Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases.
Targets&IC50	ETB:569 nM (Ki), ETA:0.679 nM (Ki)
In vitro	Nebentan potassium also inhibited endothelin-1-induced vasoconstriction in isolated rat aorta with a pA(2) value of 7.6[1].
In vivo	In medullary rats, the DR(2) values of Nebentan potassium are 0.53 mg/kg and 0.77 mg/kg, respectively. When administered orally at 1 mg/kg, Nebentan potassium maintains its antagonistic effects in conscious rats for over 6.5 hours[1].
Synonyms	YM598

Chemical Properties

Molecular Weight	529.61
Formula	C₂₄H₂₀KN₅O₅S
Cas No.	342005-82-7
Smiles	O=S([N-]C1=NC(C2=NC=CC=N2)=NC(OC)=C1OC3=C(C=CC=C3)OC)(/C=C/C4=CC=CC=C4)=O.[K+]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (188.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8882 mL	9.4409 mL	18.8818 mL	94.4091 mL
5 mM	0.3776 mL	1.8882 mL	3.7764 mL	18.8818 mL
10 mM	0.1888 mL	0.9441 mL	1.8882 mL	9.4409 mL
20 mM	0.0944 mL	0.4720 mL	0.9441 mL	4.7205 mL
50 mM	0.0378 mL	0.1888 mL	0.3776 mL	1.8882 mL
100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.9441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc