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(+)-JNJ-A07

🥰Excellent
TargetMol
Catalog No. T64092Cas No. 2135640-93-4

(+)-JNJ-A07 is a pan-serotypic dengue virus inhibitor that targets NS3-NS4B interaction with high potency. (+)-JNJ-A07 has antiviral activity and can be used to study dengue virus infections.

(+)-JNJ-A07
Other Forms of (+)-JNJ-A07:
(-)-JNJ-A07T640912135640-92-3
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(+)-JNJ-A07

🥰Excellent
TargetMol
Purity: 99.80%
Catalog No. T64092Cas No. 2135640-93-4
(+)-JNJ-A07 is a pan-serotypic dengue virus inhibitor that targets NS3-NS4B interaction with high potency. (+)-JNJ-A07 has antiviral activity and can be used to study dengue virus infections.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$66In StockIn Stock
5 mg$158In StockIn Stock
10 mg$248In StockIn Stock
25 mg$397In StockIn Stock
50 mg$569In StockIn Stock
100 mg$786In StockIn Stock
200 mg$1,080-In Stock
1 mL x 10 mM (in DMSO)$198In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.80%
ee:99.60%
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COA CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity
Description
(+)-JNJ-A07 is a pan-serotypic dengue virus inhibitor that targets NS3-NS4B interaction with high potency. (+)-JNJ-A07 has antiviral activity and can be used to study dengue virus infections.
In vitro
(+)-JNJ-A07 exhibits nanomolar to picomolar activity against clinical isolates of 21 serotypes of dengue fever virus and can prevent the formation of viral replication complexes by blocking the interaction between two viral proteins (NS3 and NS4B)[1].
Chemical Properties
Molecular Weight578.96
FormulaC28H26ClF3N2O6
Cas No.2135640-93-4
SmilesC(C(NC1=CC(OCCCC(O)=O)=CC(OC)=C1)C2=CC=C(Cl)C=C2)(=O)N3C=4C(CC3)=CC=C(OC(F)(F)F)C4
Relative Density.1.409 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (138.18 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.7 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7272 mL8.6362 mL17.2724 mL86.3618 mL
5 mM0.3454 mL1.7272 mL3.4545 mL17.2724 mL
10 mM0.1727 mL0.8636 mL1.7272 mL8.6362 mL
20 mM0.0864 mL0.4318 mL0.8636 mL4.3181 mL
50 mM0.0345 mL0.1727 mL0.3454 mL1.7272 mL
100 mM0.0173 mL0.0864 mL0.1727 mL0.8636 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VirusProteaseVirus ProteaseDengue Fever virus
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