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A-582941 dihydrochloride

Name: A-582941 dihydrochloride
Brand: TargetMol
SKU: T22016
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22016Cas No. 848591-90-2

Alias A 582941

A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial

A-582941 dihydrochloride

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Purity: 99.55%

Catalog No. T22016Alias A 582941Cas No. 848591-90-2

A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$562	In Stock	In Stock
200 mg	$783	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.55%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial
Targets&IC50	α7 nAChR:10.8 nM (Ki, for rat α7 receptors), α7 nAChR:16.7 nM (Ki, for human α7 receptors), 5-HT3 receptor:150 nM (Ki)
In vivo	A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs.?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.
Synonyms	A 582941

Chemical Properties

Molecular Weight	353.29
Formula	C₁₇H₂₂Cl₂N₄
Cas No.	848591-90-2
Smiles	CN(CC1C2)CC1CN2C3=NN=C(C4=CC=CC=C4)C=C3.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (155.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8305 mL	14.1527 mL	28.3054 mL	141.5268 mL
5 mM	0.5661 mL	2.8305 mL	5.6611 mL	28.3054 mL
10 mM	0.2831 mL	1.4153 mL	2.8305 mL	14.1527 mL
20 mM	0.1415 mL	0.7076 mL	1.4153 mL	7.0763 mL
50 mM	0.0566 mL	0.2831 mL	0.5661 mL	2.8305 mL
100 mM	0.0283 mL	0.1415 mL	0.2831 mL	1.4153 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc