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A-582941 dihydrochloride

Name: A-582941 dihydrochloride
Brand: TargetMol
SKU: T22016
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22016Cas No. 848591-90-2

Alias A 582941

A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial

A-582941 dihydrochloride

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Purity: 99.55%

Catalog No. T22016Alias A 582941Cas No. 848591-90-2

A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$81	In Stock
10 mg	$123	In Stock
25 mg	$247	In Stock
50 mg	$372	In Stock
100 mg	$562	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Purity:99.55%

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COA LCMS

Product Introduction

Bioactivity

Description	A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial
Targets&IC50	5-HT3 receptor:150 nM (Ki), α7 nAChR:10.8 nM (Ki, for rat α7 receptors), α7 nAChR:16.7 nM (Ki, for human α7 receptors)
In vivo	A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs.?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.
Synonyms	A 582941

Chemical Properties

Molecular Weight	353.29
Formula	C₁₇H₂₂Cl₂N₄
Cas No.	848591-90-2
Smiles	CN(CC1C2)CC1CN2C3=NN=C(C4=CC=CC=C4)C=C3.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (155.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8305 mL	14.1527 mL	28.3054 mL	141.5268 mL
5 mM	0.5661 mL	2.8305 mL	5.6611 mL	28.3054 mL
10 mM	0.2831 mL	1.4153 mL	2.8305 mL	14.1527 mL
20 mM	0.1415 mL	0.7076 mL	1.4153 mL	7.0763 mL
50 mM	0.0566 mL	0.2831 mL	0.5661 mL	2.8305 mL
100 mM	0.0283 mL	0.1415 mL	0.2831 mL	1.4153 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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