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Benzylacyclouridine (BAU) is a specific and orally available uridine phosphorylase (UrdPase) inhibitor that plays a major role in the regulation of uridine metabolism and is able to potentiate the toxicity of 5-Fluorouracil against human prostate cancer cells with antitumor potential.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mL x 10 mM (in DMSO) | $152 | 7-10 days |
Description | Benzylacyclouridine (BAU) is a specific and orally available uridine phosphorylase (UrdPase) inhibitor that plays a major role in the regulation of uridine metabolism and is able to potentiate the toxicity of 5-Fluorouracil against human prostate cancer cells with antitumor potential. |
In vitro | Benzylacyclouridine (BAU) is a potent and selective inhibitor of uridine phosphorylase (UrdPase). In multiple human cancer cell lines, BAU increased 5-fluorouracil (5-FU) cytotoxicity when administered prior to 5-FU, demonstrating its potential to sensitize tumor cells to chemotherapy by inhibiting UrdPase activity[1]. |
In vivo | In dogs and pigs, oral or intravenous Benzylacyclouridine (30 or 120 mg/kg) markedly inhibited uridine degradation and produced sustained increases in plasma uridine (t₁/₂ = 1.8–3.6 h in dogs, 1.6–2.3 h in pigs; tissue:plasma ratio ≈ 0.7). In a Phase I trial in advanced cancer patients, oral Benzylacyclouridine at 200–1600 mg/m² produced dose-linear pharmacokinetics (Cmax = 19–99 μM; t₁/₂ = 3.0–3.9 h) and raised plasma uridine by 120–250%. No dose-limiting toxicity was observed, and 800 mg/m² is recommended as the Phase II starting dose when combined with 5-FU[1]. |
Alias | IND039655, IND 039655, BAU, 5-Benzylacyclouridine |
Molecular Weight | 276.29 |
Formula | C14H16N2O4 |
Cas No. | 82857-69-0 |
Smiles | O=C1NC(=O)N(C=C1CC=2C=CC=CC2)COCCO |
Relative Density. | 1.290 g/cm3 (Predicted) |
Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80.00 mg/mL (289.55 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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