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Benzylacyclouridine

Name: Benzylacyclouridine
Brand: TargetMol
SKU: T40932
Rating: 4.5 (1 reviews)

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Catalog No. T40932Cas No. 82857-69-0

Alias IND039655, IND 039655, BAU, 5-Benzylacyclouridine

Benzylacyclouridine (BAU) is a specific and orally available uridine phosphorylase (UrdPase) inhibitor that plays a major role in the regulation of uridine metabolism and is able to potentiate the toxicity of 5-Fluorouracil against human prostate cancer cells with antitumor potential.

Benzylacyclouridine

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Catalog No. T40932Alias IND039655, IND 039655, BAU, 5-BenzylacyclouridineCas No. 82857-69-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mL x 10 mM (in DMSO)	$152	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Benzylacyclouridine (BAU) is a specific and orally available uridine phosphorylase (UrdPase) inhibitor that plays a major role in the regulation of uridine metabolism and is able to potentiate the toxicity of 5-Fluorouracil against human prostate cancer cells with antitumor potential.
In vitro	Benzylacyclouridine (BAU) is a potent and selective inhibitor of uridine phosphorylase (UrdPase). In multiple human cancer cell lines, BAU increased 5-fluorouracil (5-FU) cytotoxicity when administered prior to 5-FU, demonstrating its potential to sensitize tumor cells to chemotherapy by inhibiting UrdPase activity[1].
In vivo	In dogs and pigs, oral or intravenous Benzylacyclouridine (30 or 120 mg/kg) markedly inhibited uridine degradation and produced sustained increases in plasma uridine (t₁/₂ = 1.8–3.6 h in dogs, 1.6–2.3 h in pigs; tissue:plasma ratio ≈ 0.7). In a Phase I trial in advanced cancer patients, oral Benzylacyclouridine at 200–1600 mg/m² produced dose-linear pharmacokinetics (Cmax = 19–99 μM; t₁/₂ = 3.0–3.9 h) and raised plasma uridine by 120–250%. No dose-limiting toxicity was observed, and 800 mg/m² is recommended as the Phase II starting dose when combined with 5-FU[1].
Synonyms	IND039655, IND 039655, BAU, 5-Benzylacyclouridine

Chemical Properties

Molecular Weight	276.29
Formula	C₁₄H₁₆N₂O₄
Cas No.	82857-69-0
Smiles	O=C1NC(=O)N(C=C1CC=2C=CC=CC2)COCCO
Relative Density.	1.290 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (289.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6194 mL	18.0969 mL	36.1939 mL	180.9693 mL
5 mM	0.7239 mL	3.6194 mL	7.2388 mL	36.1939 mL
10 mM	0.3619 mL	1.8097 mL	3.6194 mL	18.0969 mL
20 mM	0.1810 mL	0.9048 mL	1.8097 mL	9.0485 mL
50 mM	0.0724 mL	0.3619 mL	0.7239 mL	3.6194 mL
100 mM	0.0362 mL	0.1810 mL	0.3619 mL	1.8097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Benzylacyclouridine