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Benzylacyclouridine

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Catalog No. T40932Cas No. 82857-69-0
Alias IND039655, IND 039655, BAU, 5-Benzylacyclouridine

Benzylacyclouridine (BAU) is a specific and orally available uridine phosphorylase (UrdPase) inhibitor that plays a major role in the regulation of uridine metabolism and is able to potentiate the toxicity of 5-Fluorouracil against human prostate cancer cells with antitumor potential.

Benzylacyclouridine

Benzylacyclouridine

😃Good
Catalog No. T40932Alias IND039655, IND 039655, BAU, 5-BenzylacyclouridineCas No. 82857-69-0
Benzylacyclouridine (BAU) is a specific and orally available uridine phosphorylase (UrdPase) inhibitor that plays a major role in the regulation of uridine metabolism and is able to potentiate the toxicity of 5-Fluorouracil against human prostate cancer cells with antitumor potential.
Pack SizePriceAvailabilityQuantity
1 mL x 10 mM (in DMSO)$1527-10 days
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Product Introduction

Bioactivity
Description
Benzylacyclouridine (BAU) is a specific and orally available uridine phosphorylase (UrdPase) inhibitor that plays a major role in the regulation of uridine metabolism and is able to potentiate the toxicity of 5-Fluorouracil against human prostate cancer cells with antitumor potential.
In vitro
Benzylacyclouridine (BAU) is a potent and selective inhibitor of uridine phosphorylase (UrdPase). In multiple human cancer cell lines, BAU increased 5-fluorouracil (5-FU) cytotoxicity when administered prior to 5-FU, demonstrating its potential to sensitize tumor cells to chemotherapy by inhibiting UrdPase activity[1].
In vivo
In dogs and pigs, oral or intravenous Benzylacyclouridine (30 or 120 mg/kg) markedly inhibited uridine degradation and produced sustained increases in plasma uridine (t₁/₂ = 1.8–3.6 h in dogs, 1.6–2.3 h in pigs; tissue:plasma ratio ≈ 0.7). In a Phase I trial in advanced cancer patients, oral Benzylacyclouridine at 200–1600 mg/m² produced dose-linear pharmacokinetics (Cmax = 19–99 μM; t₁/₂ = 3.0–3.9 h) and raised plasma uridine by 120–250%. No dose-limiting toxicity was observed, and 800 mg/m² is recommended as the Phase II starting dose when combined with 5-FU[1].
AliasIND039655, IND 039655, BAU, 5-Benzylacyclouridine
Chemical Properties
Molecular Weight276.29
FormulaC14H16N2O4
Cas No.82857-69-0
SmilesO=C1NC(=O)N(C=C1CC=2C=CC=CC2)COCCO
Relative Density.1.290 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80.00 mg/mL (289.55 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6194 mL18.0969 mL36.1939 mL180.9693 mL
5 mM0.7239 mL3.6194 mL7.2388 mL36.1939 mL
10 mM0.3619 mL1.8097 mL3.6194 mL18.0969 mL
20 mM0.1810 mL0.9048 mL1.8097 mL9.0485 mL
50 mM0.0724 mL0.3619 mL0.7239 mL3.6194 mL
100 mM0.0362 mL0.1810 mL0.3619 mL1.8097 mL

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