Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (5-FU) and its derivatives.
Pack Size | Availability | Price/USD | Quantity |
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1 mL * 10 mM (in DMSO) | 5 days | $ 152.00 |
Description | Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (5-FU) and its derivatives. |
In vitro | Benzylacyclouridine increases 5-FU-induced cytotoxicity in a number of human cancer cell lines[1]. Benzylacyclouridine (20-100 μM) reduces the rapid clearance of trace amounts of either [ 14 C]uridine or hyperphysiologic concentrations of non-labeled uridine by the isolated rat liver perfused with an artificial oxygen carrier[2]. |
In vivo | Benzylacyclouridine, administered either orally (p.o.) or intravenously (i.v.), effectively inhibits the rapid conversion of a tracer dose of uridine to uracil in both dogs and pigs[1]. In dogs, the compound demonstrates a half-life (t 1/2) ranging between 1.8 to 3.6 hours and achieves bioavailability levels of 85% at a dosage of 30 mg/kg and 42.5% at 120 mg/kg[1]. When administered to pigs at a dosage of 120 mg/kg, benzylacyclouridine shows a half-life (t 1/2) of 1.6 to 2.3 hours, with a bioavailability of 40%[1]. |
Synonyms | 5-Benzylacyclouridine, BAU |
Molecular Weight | 276.2878 |
Formula | C14H16N2O4 |
CAS No. | 82857-69-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Benzylacyclouridine 82857-69-0 5-Benzylacyclouridine BAU inhibitor inhibit