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Vasopressin

Name: Vasopressin
Brand: TargetMol
SKU: T9857
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9857Cas No. 11000-17-2

Alias argipressin, arginine vasopressin (AVP), antidiuretic hormone (ADH)

Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis. Vasopressin is involved in the regulation process of hypothalamic-pituitary-adrenal axis, increasing the amount of solute free water reabsorbed from the renal tubule's colate back into the circulation, narrowing arteries to increase pressure, enhancing the stimulating effect of corticotropin releasing factor to regulate pituitary corticotropin secretion. Vasopressin acts as a neurotransmitter during nerve conduction by binding to specific G-protein-coupled receptors.

Vasopressin

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Catalog No. T9857Alias argipressin, arginine vasopressin (AVP), antidiuretic hormone (ADH)Cas No. 11000-17-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$97	In Stock	In Stock
50 mg	$163	-	In Stock
100 mg	$243	-	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis. Vasopressin is involved in the regulation process of hypothalamic-pituitary-adrenal axis, increasing the amount of solute free water reabsorbed from the renal tubule's colate back into the circulation, narrowing arteries to increase pressure, enhancing the stimulating effect of corticotropin releasing factor to regulate pituitary corticotropin secretion. Vasopressin acts as a neurotransmitter during nerve conduction by binding to specific G-protein-coupled receptors.
In vitro	AVP (0.01 nM-1 μM) induces Ca2+ elevation in Chinese hamster ovary cells expressing rat or human V1b receptors.[1]
In vivo	Vasopressin (0.03-0.3 μg/kg; i.p.) enhances corticotropin release elicited by exogenous corticoliberin and amplifies corticotropin secretion following dehydration.[1] Vasopressin (0.001-0.1 mg/kg; i.p.) significantly promotes proximity, wherein rats encountering each other for the first time exhibit passive side-by-side positioning.[2]
Synonyms	argipressin, arginine vasopressin (AVP), antidiuretic hormone (ADH)

Chemical Properties

Molecular Weight	1084.24
Formula	C₄₆H₆₅N₁₅O₁₂S₂
Cas No.	11000-17-2
Smiles	O=C([C@@H](N)CSSC[C@H](NC1=O)C(N2[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCNC(N)=N)=O)CCC2)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC(N)=O)=O)CCC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4
Relative Density.	no data available
Sequence	Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-NH2
Sequence Short	CYFQNCPR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (83.01 mM), Sonication is recommended.

H2O: 45 mg/mL (41.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9223 mL	4.6115 mL	9.2231 mL	46.1153 mL
5 mM	0.1845 mL	0.9223 mL	1.8446 mL	9.2231 mL
10 mM	0.0922 mL	0.4612 mL	0.9223 mL	4.6115 mL
20 mM	0.0461 mL	0.2306 mL	0.4612 mL	2.3058 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0184 mL	0.0922 mL	0.1845 mL	0.9223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc