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2-Ethylpyrazine

Name: 2-Ethylpyrazine
Brand: TargetMol
SKU: T38248
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38248Cas No. 13925-00-3

2-Ethylpyrazine is present in roasted coffee beans and is a volatile compound .2-Ethylpyrazine induces vasodilation through the activity of endothelium-derived relaxing factors.2-Ethylpyrazine activates NO synthesis through the action of endothelial endothelial NO synthase.2-Ethylpyrazine induces vasodilation by inducing NO release and increasing peripheral blood flow to induce vasodilation.

2-Ethylpyrazine

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Purity: 99.62%

Catalog No. T38248Cas No. 13925-00-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.62%

Appearance:Liquid

Color:White

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COA GC HNMR

Product Introduction

Bioactivity

Description	2-Ethylpyrazine is present in roasted coffee beans and is a volatile compound .2-Ethylpyrazine induces vasodilation through the activity of endothelium-derived relaxing factors.2-Ethylpyrazine activates NO synthesis through the action of endothelial endothelial NO synthase.2-Ethylpyrazine induces vasodilation by inducing NO release and increasing peripheral blood flow to induce vasodilation.
In vitro	2-ethylpyrazine (2-EP) (100 µM or 1 mM) induces vasodilatation through the activities of endothelium-derived relaxing factors. 2-EP activates NO synthesis through the effect of endothelial NO synthase in the endothelium. As a result, cyclic GMP levels rise in smooth muscle cells and vasodilatation is induced.[1]
In vivo	2-ethylpyrazine (2-EP) (10, 100 μg/kg; injected; Wistar rats ) increases peripheral blood flow in rats.[1]

Chemical Properties

Molecular Weight	108.14
Formula	C₆H₈N₂
Cas No.	13925-00-3
Smiles	CCc1cnccn1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (832.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (30.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.2473 mL	46.2364 mL	92.4727 mL	462.3636 mL
5 mM	1.8495 mL	9.2473 mL	18.4945 mL	92.4727 mL
10 mM	0.9247 mL	4.6236 mL	9.2473 mL	46.2364 mL
20 mM	0.4624 mL	2.3118 mL	4.6236 mL	23.1182 mL
50 mM	0.1849 mL	0.9247 mL	1.8495 mL	9.2473 mL
100 mM	0.0925 mL	0.4624 mL	0.9247 mL	4.6236 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc