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Methyl 3-(2,4-dihydroxyphenyl)propionate
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Catalog No. TN4527Cas No. 17422-90-1
Methyl 3-(2,4-dihydroxyphenyl)propionate is a novel vitamin E derivative that inhibits tyrosinase, which is an antioxidant and inhibits UV-B-induced hyperpigmentation, with potential whitening effects.
Methyl 3-(2,4-dihydroxyphenyl)propionate
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Purity: 98.62%
Catalog No. TN4527Cas No. 17422-90-1
Methyl 3-(2,4-dihydroxyphenyl)propionate is a novel vitamin E derivative that inhibits tyrosinase, which is an antioxidant and inhibits UV-B-induced hyperpigmentation, with potential whitening effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $31 | - | In Stock | |
| 200 mg | $44 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.62%
Appearance:Viscous
Color:Yellow
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Methyl 3-(2,4-dihydroxyphenyl)propionate is a novel vitamin E derivative that inhibits tyrosinase, which is an antioxidant and inhibits UV-B-induced hyperpigmentation, with potential whitening effects. |
| In vitro | Methods: A novel vitamin E derivative, (6"-hydroxy-2",5",7",8"-tetramethylchroman-2"-yl)methyl 3-(2,4-dihydroxyphenyl)propionate (TM4R), which has a chromanoxy ring and a 4-substituted resorcinol moiety, was synthesized and evaluated for its inhibitory activity against tyrosinase, antioxidant capacity, and lightening effect on ultraviolet B (UVB)-induced hyperpigmentation. Results: Methyl 3-(2,4-dihydroxyphenyl)propionate exhibited potent inhibitory activity against tyrosinase, the rate-limiting enzyme in melanogenesis. The scavenging activity of methyl 3-(2,4-dihydroxyphenyl)propionate against 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals was found to be almost the same as that of α-tocopherol. Furthermore, an effective whitening effect was observed after topical application of methyl 3-(2,4-dihydroxyphenyl)propionate on UVB-stimulated pigmented dorsal skin of brown guinea pigs. Conclusion: These Results suggest that methyl 3-(2,4-dihydroxyphenyl)propionate may be an effective skin-whitening agent, possibly by inhibiting tyrosinase activity and biological responses induced by reactive oxygen species.[1] |
| Molecular Weight | 196.2 |
| Formula | C10H12O4 |
| Cas No. | 17422-90-1 |
| Smiles | O=C(OC)CCC1=CC=C(O)C=C1O |
| Relative Density. | 1.260 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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