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AZD9898

Name: AZD9898
Brand: TargetMol
SKU: T14387
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14387Cas No. 2042347-69-1

AZD9898 is an inhibitor of leukotriene-C4 synthetase with an IC50 of 0.28 nM. AZD9898 can be used in studies about asthma. AZD9898 mitigates the GABA binding and hepatic toxicity signal.

AZD9898

🥰Excellent

Purity: 99.26%

Catalog No. T14387Cas No. 2042347-69-1

AZD9898 is an inhibitor of leukotriene-C4 synthetase with an IC50 of 0.28 nM. AZD9898 can be used in studies about asthma. AZD9898 mitigates the GABA binding and hepatic toxicity signal.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$215	-	In Stock
5 mg	$538	-	In Stock
10 mg	$790	-	In Stock
25 mg	$1,270	-	In Stock
50 mg	$1,690	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.26%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AZD9898 is an inhibitor of leukotriene-C4 synthetase with an IC50 of 0.28 nM. AZD9898 can be used in studies about asthma. AZD9898 mitigates the GABA binding and hepatic toxicity signal.
Targets&IC50	LTC4S:0.28 nM
In vivo	AZD9898 (10 and 100 mg/kg; oral) is well tolerated and shows no safety concerns[1].

Chemical Properties

Molecular Weight	457.83
Formula	C₂₀H₁₉ClF₃N₃O₄
Cas No.	2042347-69-1
Smiles	COc1nc(cnc1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC(C)(C)F)c1cc(Cl)c(F)cc1F
Relative Density.	1.463 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (491.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1842 mL	10.9211 mL	21.8422 mL	109.2108 mL
5 mM	0.4368 mL	2.1842 mL	4.3684 mL	21.8422 mL
10 mM	0.2184 mL	1.0921 mL	2.1842 mL	10.9211 mL
20 mM	0.1092 mL	0.5461 mL	1.0921 mL	5.4605 mL
50 mM	0.0437 mL	0.2184 mL	0.4368 mL	2.1842 mL
100 mM	0.0218 mL	0.1092 mL	0.2184 mL	1.0921 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc