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anti-TNBC agent-10

Name: anti-TNBC agent-10
Brand: TargetMol
SKU: T212083
Rating: 4.5 (1 reviews)

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Catalog No. T212083Cas No. 2923722-02-3

Anti-TNBC agent-10 is an agent targeting triple-negative breast cancer (TNBC). It demonstrates potent anti-TNBC activity against BT549 cells with an IC50 of 0.018 μM and remains active in MDA-MB-231 cells with an IC50 of 4.16 μM. In mice with subcutaneous MDA-MB-231 TNBC xenografts, it shows significant antitumor efficacy. Anti-TNBC agent-10 is applicable in TNBC studies.

anti-TNBC agent-10

😃Good

Catalog No. T212083Cas No. 2923722-02-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Anti-TNBC agent-10 is an agent targeting triple-negative breast cancer (TNBC). It demonstrates potent anti-TNBC activity against BT549 cells with an IC50 of 0.018 μM and remains active in MDA-MB-231 cells with an IC50 of 4.16 μM. In mice with subcutaneous MDA-MB-231 TNBC xenografts, it shows significant antitumor efficacy. Anti-TNBC agent-10 is applicable in TNBC studies.
In vivo	As an anti-TNBC agent, Analog 9 (25 mg/kg, intraperitoneal injection, once daily for 5 consecutive days [Q1Dx5], over a period of 2 weeks) demonstrated significant antitumor efficacy in athymic nude mice bearing subcutaneous MDA-MB-231 TNBC xenografts.

Chemical Properties

Molecular Weight	337.23
Formula	C₁₁H₁₁F₄N₅O₃
Cas No.	2923722-02-3
Smiles	F[C@@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(C(F)(F)F)N3)O[C@H](CO)[C@H]1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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