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Anticancer agent 73

Name: Anticancer agent 73
Brand: TargetMol
SKU: T60420
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60420Cas No. 124811-87-6

Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells.

Anticancer agent 73

🥰Excellent

Purity: 99.19%

Catalog No. T60420Cas No. 124811-87-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	-	In Stock
25 mg	$68	-	In Stock
50 mg	$103	-	In Stock
100 mg	$155	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.19%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells.
In vitro	Anticancer agent 73 (compound CIB-3b) (10 μM; 6 h) elevates E-cadherin expression and reduces fibronectin, N-cadherin, and vimentin protein levels in SK-HEP-1 cells. It also inhibits the proliferation and migration of SK-HEP-1, HCCLM3, and MHCC97L cells by impeding miRNA biogenesis.[1]
In vivo	Anticancer agent 73 (compound CIB-3b) (10, 25, and 50 mg/kg; i.v.; every 2 days for 4 weeks; SCID mice) diminishes the proliferation and migration of both SK-HEP-1 cells and SK-HEP-1 cells implanted in SCID mice.[1]

Chemical Properties

Molecular Weight	261.27
Formula	C₁₄H₁₅NO₄
Cas No.	124811-87-6
Smiles	CCOC(=O)c1nc(oc1C)-c1ccc(OC)cc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (344.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8275 mL	19.1373 mL	38.2746 mL	191.3729 mL
5 mM	0.7655 mL	3.8275 mL	7.6549 mL	38.2746 mL
10 mM	0.3827 mL	1.9137 mL	3.8275 mL	19.1373 mL
20 mM	0.1914 mL	0.9569 mL	1.9137 mL	9.5686 mL
50 mM	0.0765 mL	0.3827 mL	0.7655 mL	3.8275 mL
100 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9137 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc