Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 368.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells. |
In vitro | Anticancer agent 73 (compound CIB-3b) (10 μM; 6 h) induces an elevation in E-cadherin expression and reduces the protein levels of fibronectin, N-cadherin, and vimentin in SK-HEP-1 cells. Furthermore, it suppresses the proliferation and migration of SK-HEP-1, HCCLM3, and MHCC97L cells by impeding miRNA biogenesis.[1] |
In vivo | Anticancer agent 73 (compound CIB-3b) (10, 25, and 50 mg/kg; i.v.; every 2 days for 4 weeks; SCID mice) diminishes the proliferation and migration of both SK-HEP-1 cells and SK-HEP-1 cells implanted in SCID mice.[1] |
Molecular Weight | 261.27 |
Formula | C14H15NO4 |
CAS No. | 124811-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (344.5 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Anticancer agent 73 124811-87-6 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor inhibit