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Picenadol

Catalog No. T68127 CAS 2650427-35-1

Synonyms: LY-150720, LY150720, LY 150720

Picenadol (LY 150720) is a racemic mixture of N-methyl-4-phenylpiperidine derivatives with agonist-antagonist opioid properties.Picenadol has central analgesic activity.

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Picenadol, CAS 2650427-35-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 130.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 480.00
25 mg	In stock	$ 786.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00

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Purity: 97.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Picenadol (LY 150720) is a racemic mixture of N-methyl-4-phenylpiperidine derivatives with agonist-antagonist opioid properties.Picenadol has central analgesic activity.

In vivo

The effects of Picenadol (LY150720) (0.3-3.0 mg/kg), its agonist (dextro) isomer LY136596 (0.3-1.7 mg/kg) and morphine (0.03-1.0 mg/kg) were studied alone and in combination with naloxone (0.001-1.0 mg/kg) in squirrel monkeys whose responding was maintained under a multiple fixed-ratio 30-response fixed-interval 5-minute (mult FR-30 FI 5-min) schedule of food presentation. LY150720, LY136596, and morphine generally decreased responding under both schedule components, although in several instances increases in responding under the FI component were noted, particularly following LY150720 and LY136596. The rate-decreasing effects of morphine, LY150720, and LY136596 were reversed by naloxone; doses of naloxone required to reverse the effects of all three drugs were comparable. When combined with morphine, naloxone restored rates and patterns of responding to control values, whereas combinations of LY150720 or LY136596 and naloxone increased responding under the FI component in excess of control values. These increases appear to be due to the anticholinergic actions of LY150720 and LY136596, as they are reversed by physostigmine (0.01 mg/kg), and similar increases are produced by scopolamine (0.01-0.1 mg/kg).[1]

Synonyms	LY-150720, LY150720, LY 150720
Molecular Weight	247.38
Formula	C16H25NO
CAS No.	2650427-35-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (222.33 mM)

References and Literature

1. Carter RB, et al. Effects of LY150720 (picenadol), a novel mixed-action opioid, on schedule-controlled responding in the squirrel monkey. Pharmacol Biochem Behav. 1984 Nov;21(5):779-86. 2. Carter RB, et al. Effects of picenadol (LY150720) and its stereoisomers on electric shock titration in the squirrel monkey. J Pharmacol Exp Ther. 1985 Aug;234(2):299-306.

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Keywords

Picenadol 2650427-35-1 Others LY-150720 LY150720 LY 150720 inhibitor inhibit

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