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Lefty-A Protein, Human, Recombinant (His)

Catalog No. TMPJ-00238
Synonyms: Endometrial bleeding-associated factor, TGFB4, TGF-β-4, EBAF, LEFTA, LEFTYA, TGF-beta-4, Left-right determination factor A, Left-right determination factor 2, Transforming growth factor beta-4, Protein lefty-2, LEFTY2, Protein lefty-A, Transforming growth factor β-4

Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins and that are necessary to form the cysteineknot structure. Its function in patterning left-right asymmetry of the developing organ systems such as the heart and lung is consistent in all vertebrate species examined. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor. It may play a role in endometrial bleeding.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Lefty-A Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 35.00
50 μg 5 days $ 110.00
500 μg 5 days $ 745.00
1 mg 5 days $ 1,180.00
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Biological Description
Technical Params
Product Properties
Description Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins and that are necessary to form the cysteineknot structure. Its function in patterning left-right asymmetry of the developing organ systems such as the heart and lung is consistent in all vertebrate species examined. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor. It may play a role in endometrial bleeding.
Species Human
Expression System Human Cells
Tag N-6His
Accession Number O00292
Synonyms Endometrial bleeding-associated factor, TGFB4, TGF-β-4, EBAF, LEFTA, LEFTYA, TGF-beta-4, Left-right determination factor A, Left-right determination factor 2, Transforming growth factor beta-4, Protein lefty-2, LEFTY2, Protein lefty-A, Transforming growth factor β-4
Amino Acid Phe78-Pro366
Construction Recombinant Human Left-right Determination Factor 2 is produced by our Mammalian expression system and the target gene encoding Phe78-Pro366 is expressed with a 6His tag at the N-terminus.
Protein Purity Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 45-50 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl，4% Sucrose，4% Mannitol，0.1% Tween80，pH6.0.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins and that are necessary to form the cysteineknot structure. Its function in patterning left-right asymmetry of the developing organ systems such as the heart and lung is consistent in all vertebrate species examined. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor. It may play a role in endometrial bleeding.

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Keywords

Lefty-A Protein, Human, Recombinant (His) LEFTY 2 Endometrial bleeding-associated factor TGFB4 TGF-β-4 TGF-b-4 EBAF LEFTA LEFTYA TGF-beta-4 LEFTY-2 Left-right determination factor A Left-right determination factor 2 TGFB-4 Transforming growth factor b-4 Transforming growth factor beta-4 Protein lefty-2 LEFTY2 Protein lefty-A TGFB 4 Transforming growth factor β-4 recombinant recombinant-proteins proteins protein

 

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