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Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated

Catalog No. TMPJ-00256
Synonyms: Transforming growth factor β-3, Latent TGF-β3, TGF-β-3, TGFβ3, TGFB3, TGF-beta-3, Transforming growth factor beta-3 proprotein

Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are three isoforms of TGFβ (TGFβ-1, -2 and -3). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF-beta RI or ALK-1, to modulate transcription through Smad phosphorylation.

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Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 900.00
100 μg 5 days $ 2,480.00
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Biological Description
Technical Params
Product Properties
Description Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are three isoforms of TGFβ (TGFβ-1, -2 and -3). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF-beta RI or ALK-1, to modulate transcription through Smad phosphorylation.
Species Human
Expression System Human Cells
Tag N-8His-Avi
Accession Number P10600
Synonyms Transforming growth factor β-3, Latent TGF-β3, TGF-β-3, TGFβ3, TGFB3, TGF-beta-3, Transforming growth factor beta-3 proprotein
Amino Acid Leu30-Ser390
Construction Biotinylated Recombinant Human Transforming Growth Factor Beta-3 Proprotein is produced by our Mammalian expression system and the target gene encoding Leu30-Ser390 (Cys33Ser) is expressed with a 8His, Avi tag at the N-terminus.
Protein Purity Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 12&37-45 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are three isoforms of TGFβ (TGFβ-1, -2 and -3). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF-beta RI or ALK-1, to modulate transcription through Smad phosphorylation.

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Keywords

Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated Transforming growth factor β-3 TGFB 3 Latent TGF-β3 TGF-β-3 TGFβ3 Transforming growth factor β-3 proprotein TGFB-3 TGFB3 TGF-beta-3 Transforming growth factor beta-3 proprotein TGFbeta3 TGF-b-3 Transforming growth factor b-3 proprotein recombinant recombinant-proteins proteins protein

 

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