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DEFB2 Protein, Mouse, Recombinant is expressed in E. coli. The accession number is P82020.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μg | $339 | 7-10 days | |
1 mg | $4,750 | 7-10 days |
Biological Activity | Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using immature human dendritic cells is in a concentration of 10-100 ng/ml. |
Description | DEFB2 Protein, Mouse, Recombinant is expressed in E. coli. The accession number is P82020. |
Species | Mouse |
Expression System | E. coli |
Tag | Tag Free |
Accession Number | P82020 |
Synonyms | mBD-2,Defensin, beta 2,Defb2 |
Construction | Ala21-Lys71 |
Protein Purity | > 98% as determined by SDS-PAGE; > 98% as determined by HPLC |
Molecular Weight | 5.5 kDa (Predicted) |
Endotoxin | < 1 EU/μg of protein by LAL method |
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in sterile deionized water or aqueous buffer containing 0.1% BSA. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
Shipping | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. |
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