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27-Hydroxycholesterol

Name: 27-Hydroxycholesterol
Brand: TargetMol
SKU: TQ0274
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0274Cas No. 20380-11-4

Alias 27-OHC, (25R)-26-Hydroxycholesterol

27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.

27-Hydroxycholesterol

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Purity: 99.82%

Catalog No. TQ0274Alias 27-OHC, (25R)-26-HydroxycholesterolCas No. 20380-11-4

27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$43	In Stock	In Stock
5 mg	$155	In Stock	In Stock
10 mg	$230	In Stock	In Stock
25 mg	$390	In Stock	In Stock
50 mg	$567	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
In vitro	27-Hydroxycholesterol activates estrogen receptors, adversely impacting prostate cancer cell lines by significantly enhancing cell proliferation in LNCaP and PC3 cells. This proliferation can be mitigated by estrogen receptor inhibitors [1]. As an endogenous selective estrogen receptor modulator, 27-Hydroxycholesterol exhibits substantial partial agonist activity across various cellular models, notably increasing gene transcription and cell proliferation in breast cancer contexts [2]. Produced from cholesterol by the enzyme CYP27A1, it plays a vital role in regulating intracellular cholesterol equilibrium. Its pro-tumorigenic effects can be diminished by either statins or directly inhibiting CYP27A1 [3]. Furthermore, 27-Hydroxycholesterol's conversion from cholesterol is crucial for LXR activation when faced with cholesterol excess [4].
Synonyms	27-OHC, (25R)-26-Hydroxycholesterol

Chemical Properties

Molecular Weight	402.65
Formula	C₂₇H₄₆O₂
Cas No.	20380-11-4
Smiles	[H][C@@]12CC[C@H]([C@H](C)CCC[C@@H](C)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Relative Density.	1.03

Storage & Solubility Information

Storage	keep away from direct sunlight,store at low temperature,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMF: 2 mg/mL (4.97 mM), Sonication is recommended. DMSO: 0.1 mg/mL (0.25 mM), Sonication is recommended. Ethanol: ≤ 20 mg/mL (49.66 mM), Sonication is recommended.
In Vivo Formulation	10% EtOH+90% Corn Oil: 1 mg/mL (2.48 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc