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Lenalidomide 5'-piperazine-7'-methoxy

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Catalog No. T207779Cas No. 2242743-87-7

Lenalidomide 5'-piperazine-7'-methoxy is a functional ligand for brain nuclei used in PROTAC research; it includes an E3 ligand with a terminal piperazine to create protein degraders featuring a rigid linker.

Lenalidomide 5'-piperazine-7'-methoxy

Lenalidomide 5'-piperazine-7'-methoxy

😃Good
Catalog No. T207779Cas No. 2242743-87-7
Lenalidomide 5'-piperazine-7'-methoxy is a functional ligand for brain nuclei used in PROTAC research; it includes an E3 ligand with a terminal piperazine to create protein degraders featuring a rigid linker.
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10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Lenalidomide 5'-piperazine-7'-methoxy is a functional ligand for brain nuclei used in PROTAC research; it includes an E3 ligand with a terminal piperazine to create protein degraders featuring a rigid linker.
In vitro
Lenalidomide 5'-piperazine-7'-methoxy is a functionalized cereblon ligand designed for PROTAC research and development. It includes an E3 ligase ligand and a terminal piperazine, facilitating further chemical modifications to create Protein Degraders with rigid linkers. This compound is part of a selection of tool molecules for PROTAC R&D.
Chemical Properties
Molecular Weight394.85
FormulaC18H23ClN4O4
Cas No.2242743-87-7
SmilesCl.O=C1NC(=O)C(N2C(=O)C3=C(OC)C=C(C=C3C2)N4CCNCC4)CC1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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