A2AAR antagonist 3

Name: A2AAR antagonist 3
Brand: TargetMol
SKU: T211007
Rating: 4.5 (1 reviews)

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Catalog No. T211007

A2AAR antagonist 3 is a potent and selective A2A adenosine receptor (A2AAR) antagonist with an IC50 value of 1.57 nM. It exhibits a high binding affinity specifically for A2AAR. In vitro studies demonstrate its good stability in rat liver microsomes, and it possesses acceptable pharmacokinetic properties in vivo. A2AAR antagonist 3 is applicable for cancer research.

A2AAR antagonist 3

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Catalog No. T211007

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	A2AAR antagonist 3 is a potent and selective A2A adenosine receptor (A2AAR) antagonist with an IC50 value of 1.57 nM. It exhibits a high binding affinity specifically for A2AAR. In vitro studies demonstrate its good stability in rat liver microsomes, and it possesses acceptable pharmacokinetic properties in vivo. A2AAR antagonist 3 is applicable for cancer research.
In vitro	A2AAR antagonist 3 (Compound 12a) at a concentration of 1 μM over 48 hours can restore IL-2 secretion in human peripheral blood mononuclear cells inhibited by NECA (1 μM, pretreated for 30 minutes). Furthermore, A2AAR antagonist 3, within a range of 3.125-100 μM over 24 hours, shows no significant toxicity to L929, H9C2, and HTX2426 cells.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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