Ferulenol, a sesquiterpene prenylated coumarin derivative, demonstrates potent antimycobacterial activity and [haemorrhagic] action by selectively targeting succinate ubiquinone reductase within the ubiquinone cycle.

At low concentrations, ferulenol suppresses ATP synthesis by targeting adenine nucleotide translocase (ANT), affecting its function without restricting mitochondrial respiration. As concentrations increase, it also reduces oxygen consumption. Specifically, ferulenol targets succinate ubiquinone reductase (SQR) within complex II, inhibiting its function without impacting the succinate dehydrogenase activity. This inhibition occurs in a concentration-dependent manner, with ferulenol's efficacy comparable to that of thenoyltrifluoroacetone (TTFA). Furthermore, ferulenol disrupts the oxidative phosphorylation process through its interactions with ANT and complex II of the respiratory chain, showcasing its multifaceted inhibitory effects on cellular energy processes.