CC0651

Name: CC0651
Brand: TargetMol
SKU: T14896
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14896Cas No. 1319207-44-7

Alias CC-0651

CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM) by blocking ubiquitin transfer to substrates, for use in cancer research.

CC0651

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Purity: 99.03%

Catalog No. T14896Alias CC-0651Cas No. 1319207-44-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$69	-	In Stock

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Purity:99.03%

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Product Introduction

Bioactivity

Description	CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM) by blocking ubiquitin transfer to substrates, for use in cancer research.
Targets&IC50	p27Kip1 ubiquitination:1.72 μM
In vitro	CC0651 (30μM) significantly inhibited the proliferation of PC-3 cells and induced the accumulation of p27Kip1, an effect that was reversed in cells with hCdc34 knocked down by shRNA [1]. CC0651 inhibited the Cdc34A-mediated ubiquitination reaction with an IC50 value of 18±1 μM. CC0651 also suppressed the spontaneous hydrolysis rate of Cdc34A-ubiquitin thioester [2].
Synonyms	CC-0651

Chemical Properties

Molecular Weight	442.29
Formula	C₂₀H₂₁Cl₂NO₆
Cas No.	1319207-44-7
Smiles	COCC(=O)N[C@@H](Cc1ccc(cc1)-c1cc(Cl)cc(Cl)c1)[C@H](O)[C@@H](O)C(O)=O
Relative Density.	1.410 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: ≥ 40 mg/mL, Sonication is recommended.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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